Talk:Xanthohumol
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error in biosynthesis figure
editHi. I was looking at the entry on "Xanthohumol" (https://en.wikipedia.org/wiki/Xanthohumol) and noted that there was an error in the figure. The compound annotated as L-phenylalanine is incorrectly drawn. I cannot change it because it is a jpg. If the original chemdraw file was available I could fix it but I would need to have the original file. Otherwise I have to draw the whole figure from scratch.
Removed statement
editThe sourced statement quoted below was removed by someone. It is recorded here for posterity.
In preliminary research, xanthohumol had free radical scavenging and anticancer properties,[1] immune-supporting activity, improved cognitive flexibility,[2] and inhibited platelet aggregation.[3]
References
- ^ Mol Cancer Ther. 2002 Sep;1(11):959-69. Cancer chemopreventive activity of Xanthohumol, a natural product derived from hop. https://www.ncbi.nlm.nih.gov/pubmed/12481418
- ^ https://www.ncbi.nlm.nih.gov/pubmed/25192637 Behav Brain Res. 2014 Sep 1;275C:1-10. doi: 10.1016/j.bbr.2014.08.045. Xanthohumol improved cognitive flexibility in young mice.
- ^ Lee; et al. (May 2012). "Xanthohumol, a Prenylated Flavonoid from Hops (Humulus lupulus), Prevents Platelet Activation in Human Platelets". Evid Based Complement Alternat Med. 2012: 852362. doi:10.1155/2012/852362. PMC 3352669. PMID 22611436.
{{cite journal}}: Explicit use of et al. in:|author=(help)CS1 maint: unflagged free DOI (link)
Wishful thinking (scant literature)
editList of potentially useful references. However, Ferk 2016 appears to be the only published clinical trial related to a health function! David notMD (talk) 10:15, 23 March 2017 (UTC)
Ferk F, Mišík M, et al. Impact of xanthohumol (a prenylated flavonoid from hops) on DNA stability and other health-related biochemical parameters: Results of human intervention trials. Mol Nutr Food Res. 2016;60(4):773-786.
Liu M, Hansen PE, et al. Pharmacological profile of xanthohumol, a prenylated flavonoid from hops (Humulus lupulus). Molecules. 2015;20(1):754-779.
Weiskirchen R, Mahli A, Weiskirchen S, Hellerbrand C. The hop constituent xanthohumol exhibits hepatoprotective effects and inhibits the activation of hepatic stellate cells at different levels. Front Physiol. 2015;6:140.
Chen X, Mukwaya E, Wong MS, Zhang Y. A systematic review on biological activities of prenylated flavonoids. Pharm Biol. 2014;52(5):655-60.
van Breemen RB, Yuan Y, et al. Pharmacokinetics of prenylated hop phenols in women following oral administration of a standardized extract of hops. Mol Nutr Food Res. 2014;58(10):1962-69.
Bolca S, Li J, et al. Disposition of hop prenylflavonoids in human breast tissue. Mol Nutr Food Res. 2010;54(Suppl 2):S284-94.
Magalhães PJ, Carvalho DO, et al. Fundamentals and health benefits of xanthohumol, a natural product derived from hops and beer. Nat Prod Commun. 2009;4(5):591-610.
Possemiers S, Bolca S, et al. The prenylflavonoid isoxanthohumol from hops (Humulus lupulus L.) is activated into the potent phytoestrogen 8-prenylnaringenin in vitro and in the human intestine. J Nutr. 2006;136(7):1862-7.
Legette L, Karnpracha C, et al. Human pharmacokinetics of xanthohumol, an antihyperglycemic flavonoid from hops. Mol Nutr Food Res. 2014;58(2):248-255.
Pichler C, Ferk F, et al. Xanthohumol prevents DNA damage by dietary carcinogens: results of a human intervention trial. Cancer Prev Res. 2017;10(2):153-160.
Abdi F, Mobedi H, Roozbeh N. Hops for menopausal vasomotor symptoms: mechanisms of action. J Menopausal Med. 2016;22(2):62-64.
- Shown here among NIH-registered studies, two by Oregon State University are completed (but no published reports, possibly indicating no or low-interest results), with one ongoing Phase I study for safety in women. JF Stevens, Oregon State, (PI lead for 2 of the NIH-registered studies) has been tracking toward clinical trials since the late 1990s. --Zefr (talk) 16:20, 23 March 2017 (UTC)