Talk:Pediatric acute-onset neuropsychiatric syndrome/Archive 1
Moved to talk, inadequate sourcing
editAnimal Studies
editAnimal studies have shown that infusion of the Abs into the basal ganglia of rats produces abnormal behaviors.[1][2] More recently, researchers at Columbia University demonstrated that passive transfer of the Abs is able to induce the abnormal movements and behaviors in recipient mice.[3] Among PANDAS patients, high Abs concentrations are found in acute serum samples; Abs titers are decreased during periods of symptom remission.[4] SandyGeorgia (Talk) 15:59, 29 March 2018 (UTC)
References
- ^ [unreliable medical source?] Hallett, JJ; Kiessling, LS (2000). "Anti-striatal antibodies in Tourette syndrome cause neuronal dysfunction". Neuroimmunology. 111: 195–202. doi:10.1016/s0165-5728(00)00320-9.
- ^ [unreliable medical source?] Taylor, JR; Peterson, BS (2002). "An animal model of Tourette's syndrome". Psychiatry. 159: 657–660. doi:10.1176/appi.ajp.159.4.657.
- ^ [non-primary source needed] Yaddanapudi, K; Villar, G (2009). "Passive transfer of streptococcus-induced antibodies reproduces behavioral disturbances in a mouse model of pediatric autoimmune neuropsychiatric disorders associated with streptococcal infection". Mol Psychiatry. 15: 712–726. doi:10.1038/mp.2009.77.
- ^ Cite error: The named reference
Kirvan 2006 21–29was invoked but never defined (see the help page).
Treatments
editFor treatment guidelines, refer to the PANDAS Physicians Network. PPN’s goal is to help medical professionals understand, diagnose and treat PANS and PANDAS. The network provides research, diagnostic, and treatment tools. PPN Guidelines for Diagnostics and Therapeutics are developed by PPN committees and advisors from the top academic medical institutions in the United States. The members have worked with, treated, and studied the patients and the disorder. PANS and PANDAS are interdisciplinary disorders, so the relevant disciplines are represented on the PPN committees and special advisory council. Some of the disciplines include: Psychiatrists, Pediatric Neurologists, Immunologists, Microbiologists, Rheumatologists, Geneticists, Otolaryngologists, etc.[1] SandyGeorgia (Talk) 15:59, 29 March 2018 (UTC)
References
- ^ [unreliable medical source?] "PANS Diagnostic Criteria | PPN". PPN. 2013-12-18. Retrieved 2016-12-07.
Immunomodulatory Therapy Study
editA placebo-controlled trial of plasmapheresis and IVIG for PANDAS was conducted at the NIH in the late 1990’s, with children randomly assigned (by the NIH pharmacy) to receive plasmapheresis (unblinded) or IVIG/sham IVIG (double blinded). At one month evaluations, placebo infusions produced no improvements in OC or tic symptoms, while 100% of the children receiving IVIG or plasmapheresis improved. The average improvement in OC symptoms was 45% for the group receiving IVIG and nearly 65% for the children receiving plasmapheresis. The results of the trial were sufficiently robust to cause the American Society of Apheresis to include plasmapheresis as a treatment option for PANDAS, as well as for Sydenham chorea.[1] SandyGeorgia (Talk) 16:08, 29 March 2018 (UTC)
References
- ^ Weinstein R (2008). "Therapeutic apheresis in neurological disorders: a survey of the evidence in support of current category I and II indications for therapeutic plasma exchange". J Clin Apher (Review). 23 (6): 196–201. doi:10.1002/jca.20178. PMID 18973115.
Not pubmed indexed
editI cannot find this source anywhere:
- Cooperstock, M; Murphy, T.K. (2016). "Clinical Management of Pediatric Acute-onset Neuropsychiatric Syndrome (PANS): Part III-Treatment and Prevention of Infections". PANS PANDAS Management If Infection. 27: 1–33.
Copyvio
editAfter finding three chunks of cut-and-paste copyvio, I removed all of the contributions from Gracejgoodwin (talk · contribs · logs). SandyGeorgia (Talk) 13:53, 31 March 2018 (UTC)
MEDRS
editPlease review WP:MEDRS and the template at the top of this page, from which reliable medical sources can be found. Please stop adding primary sources. SandyGeorgia (Talk) 16:49, 11 May 2018 (UTC)