Talk:Oxeladin
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Etilmorphin edit
Is this Ethylmorphine? Biscuittin (talk) 10:38, 2 July 2011 (UTC)
Bequisan edit
Bequisan is not Oxeladin, see [1]. This leads me to wonder whether the whole article is a hoax. Biscuittin (talk) 10:56, 2 July 2011 (UTC)
- The Bequisan link above is a puzzle. It seems to be an advertisement for Webber's Cough Cold Syrup (which might be Oxeladin) superimposed on a data sheet for Extraderm Emollient Cream (which clearly isn't Oxeladin). Can anyone explain it? Biscuittin (talk) 11:33, 2 July 2011 (UTC)
Possible hoax edit
I have removed the Hoax tag because I have found a WHO ref. [2] Biscuittin (talk) 11:13, 2 July 2011 (UTC)
Thinly veiled conflict of interest edit
The entire article reeks of conflict of interest. I've rarely seen pharmacology articles praising a drug that much, let alone with that amount of unsubstantiated claims. There is also no explanation of its actual mechanism of action, and much like the (probably scam) medicine pholcodine, its sellers claim that it somehow selectively acts on the cough center. For bloodborne drugs in general, there is no way of selectively acting on specific parts of the nervous system other than targeting receptors or receptor sub-types that are specific to said parts : the cough center does not have that kind of target. Such claims are unfortunately very common, but nonetheless nonsensical.
Also noteworthy :
- Oxeladin was found to be carcinogenic and subsequently withdrawn from the market in most of the English-speaking world since 1976.
- Based on the biological activity of structurally related drugs Butamirate, PRE-084 and Pentoxyverine, Oxeladin is likely a sigma-1 receptor agonist. This is also suggested by its side effects profile. Again, the cough center does not have its own specific target : sigma receptors are expressed throughout the nervous system indiscriminately. Sigma agonists do have cough suppressant effects though.