Talk:N-Desalkylflurazepam

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Contradictions edit

Latest comment: 9 years ago2 comments1 person in discussion

This article currently contains a mix of information about two distinct chemical compounds:

The chemical structure image, formula, molecular mass, and the ChEMBL link refer to one compound (which has an aminoethyl side change on the benzodiazepine amide nitrogen).
The synonym "N-desalkyl-2-oxoquazepam", the PubChem link, and the ChemSpider link refer to a second compound (which has no side chain on the benzodiazepine amide nitrogen).

The chemical name used as a title is vague enough to be able to apply to either compound, and it may be that the chemical literature applies that name to both of the compounds. It is unclear to me which of the two the text is intended to refer to. In any case, the article is currently misleading. If this can't be cleared up, the article should probably be deleted. I'm not sure that either compound is notable - they are metabolites of related pharmaceutical drugs, quazepam and flurazepam, and anything worth saying about these metabolites could probably be best said at quazepam and flurazepam rather than in standalone articles anyway. -- Ed (Edgar181) 19:18, 12 February 2015 (UTC)Reply

With some literature searching, I have resolved the contradiction and fixed the article. #2 above is a notable active metabolite of several benzodiazepine drugs. -- Ed (Edgar181) 14:55, 13 February 2015 (UTC)Reply

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