Talk:Methylthioninium chloride

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I'd much rather have this article at the drug's chemical name but as of right now there is so little information available. This compound does not even appear in a literature search, which means either their study is unpublished or very new.--VectorPotential Talk 12:48, 30 July 2008 (UTC)

The information in the article right now is cobbled together from various AP stories and 1 BBC report. If anyone has more appropriate sources or the name of a specific publication in a reputable journal please add them in place of the sources I'm using now.--VectorPotential Talk 12:50, 30 July 2008 (UTC)

methylthioninium chloride, active ingredient or actual compound?

A few of the AP stories I've read refer to methylthioninium chloride as one of the active ingredients in 'rember'. However the BBC story doesn't make any distinction between the two and suggests that rember = methylthioninium chloride. Someone is going to have to decide if this belongs in a separate article or not. If anyone wishes to turn this into a redirect to methylthioninium chloride there'd be no objection, but I'd prefer to have a definitive answer to this question before resolving this issue. --VectorPotential Talk 12:55, 30 July 2008 (UTC)

I did some medical school, I think the TAUrx product looks like the best hope at the moment. They already did a lot of trials on Rember, and now are doing phase III trials on an even better version of it. Thing is, it wont be on the market until 2013 my dad's in early stage AD, hope he holds out that long. These people are slow because of finacial, lawsuit issues etc. — Preceding unsigned comment added by 187.132.134.232 (talk) 02:27, 18 June 2011 (UTC)

further investigation

I finally tracked down some related publications by searching directly for Professor Claude Wischik. While he has published extensively on the subject of Tau Proteins and their role in neuropathology he doesn't seem to have published much recently. Since he's the only researcher in the BBC article mentioned by name it makes it hard to track down any recent papers on the subject.--VectorPotential Talk 13:17, 30 July 2008 (UTC)

Wischik has been on this topic for quite a while. See PMID 8855335 for an early paper.

It seems clear from PubChem that MTC is simply a salt of Methylene blue, but I'll defer to the chemists in the crowd. I suppose rember could have some delivery-system magic yet to be disclosed. MB is available over the counter some places. LeadSongDog (talk) 22:13, 30 July 2008 (UTC)

To be honest I didn't get very far with my search, as silly as it sounds my efforts were complicated by the fact that when I ran a journal search for 'Rember' I came up with dozens of entries for an author whose last name was Rember. It seems my journal finding skills are somewhat out of practice. (: And yes, it does seem that this is just a simple inhibitor, not really sure why I thought it was more complicated than that. My gut instinct told me that if it was that successful there must be more to it than that like MTC and some small peptide or something like that. Guess that's why it never pays to make assumptions without investigating further. (: VectorPotential Talk 22:35, 30 July 2008 (UTC)

RxMed has some interesting words too...LeadSongDog (talk) 22:36, 30 July 2008 (UTC)

This speaks to mechanism of action: PMID 18619417 LeadSongDog (talk) 13:49, 18 August 2008 (UTC)

related publication

Probably more related to methylene blue itself, but here's a paper in Biochemistry by another group on methylene blue inhibiting amyloid oligomerization by promoting fibrillization, related to Alzheimer's Disease. Paper was published earlier this spring (vol. 46, 8850-8860). Dr. Cash (talk) 15:17, 30 July 2008 (UTC)

Template:Lowercase

Why is there a {{Lowercase}} template at the top of the article? Isn't "Rember" meant to be spelt with the capital letter as it's the name of the drug, it's spelt everywhere with an uppercase. steveking89 21:59, 30 July 2008 (UTC)

The papers have been spelling it as "rember^TM", but we don't mark trademarks per WP:MOS. LeadSongDog (talk) 22:43, 30 July 2008 (UTC)

Rember - because Altzheimer's patients could not remember all of remember?

Anything on this drug's odd and possibly insulting name? —Preceding unsigned comment added by 131.230.42.64 (talk) 17:29, 5 November 2008 (UTC)

Doesn't look like it. steveking89 18:31, 5 November 2008 (UTC)

uh, what? It may be a pun on "remember" but I don't see how that's insulting. --86.152.126.227 (talk) 20:54, 17 February 2009 (UTC)

I can't get away from the feeling that the name arose from a small child pleading with an elderly relative. I also don't think it's a pun - a pun would be in poor taste. This is just a contraction of a word pertinent to the drug's function. It's the same base level word-play as in Stilnox etc. I've only come back to this, five years late, because the company I work for released their first batch of methylene blue yesterday. — Preceding unsigned comment added by 125.255.170.178 (talk) 22:37, 6 January 2015 (UTC)

Further study

Apparently Wischik found a synergism between MTC and rivastigmine:

• "Methylthioninium chloride reverses cognitive deficits induced by scopolamine: comparison with rivastigmine". Psychopharmacology (Berl). 202 (1–3): 53–65. 2009 Jan. PMID 19005644. {{cite journal}}: Check date values in: |date= (help); Cite has empty unknown parameter: |1= (help); Cite uses deprecated parameter |authors= (help)

But I don't see anything more recent published. User:LeadSongDog come howl 13:56, 12 March 2010 (UTC)

Updates seem encouraging, but no further word on phase III trial.

• Baloyannis SJ (2011 September 12). "Mitochondria Are Related to Synaptic Pathology in Alzheimer's Disease". Int J Alzheimers Dis. 2011: 305395. doi:10.4061/2011/305395. PMC 3171689. PMID 21922047. {{cite journal}}: Check date values in: |date= (help)CS1 maint: unflagged free DOI (link)
• Facecchia K, Fochesato LA, Ray SD, Stohs SJ, Pandey S (2011 Jul 14). "Oxidative toxicity in neurodegenerative diseases: role of mitochondrial dysfunction and therapeutic strategies". J Toxicol. 2011: 683728. PMC 3139184. PMID 21785590. {{cite journal}}: Check date values in: |date= (help)CS1 maint: multiple names: authors list (link)
• Atamna H, Kumar R (2010). "Protective role of methylene blue in Alzheimer's disease via mitochondria and cytochrome c oxidase". J Alzheimers Dis. 20 (Suppl 2): S439-52. PMID 20463399.
• Kumar R, Atamna H (2011 Mar 3). "Therapeutic approaches to delay the onset of Alzheimer's disease". J Aging Res. 2011: 820903. PMC 3056246. PMID 21423548. {{cite journal}}: Check date values in: |date= (help)

Someone want to do the honours? LeadSongDog come howl! 22:22, 20 September 2011 (UTC)

Merge with the article on Methylene blue

This is the same chemical. Why different articles? Maybe make a "pharmacological uses" section under the original article on metylene blue? — Preceding unsigned comment added by 37.120.62.186 (talk) 21:21, 8 June 2015 (UTC)