Talk:Laninamivir

Latest comment: 8 years ago by 137.222.114.241 in topic Laninamivir Structure Incorrect?


The structure for Laninamivir as pictured is incorrect. It should be acylated by an octoyl group on the 3-positioned hydroxy.

Xenobiotica, 2010; 40(3): 207–216 Address for Correspondence: K. Koyama, Drug Metabolism & Pharmacokinetics Research Laboratories, Daiichi Sankyo Co., Ltd, 1-2-58, Hiromachi, Shinagawa-ku, Tokyo 140-8710, Japan. Tel: 81-3-3492-3131. Fax: 81-3-5436-8567. E-mail: koyama.kumiko.hv@daiichisankyo.co.jp RESEARCH ARTICLE Pharmacokinetics and disposition of CS-8958, a long- acting prodrug of the novel neuraminidase inhibitor laninamivir in rats K. Koyama, M. Takahashi, N. Nakai, H. Takakusa, T. Murai, M. Hoshi, N. Yamamura, N. Kobayashi, and O. Okazaki —Preceding unsigned comment added by 169.237.38.226 (talk) 08:26, 5 May 2010 (UTC)Reply

Laninamivir Structure Incorrect?

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Hi, I believe that the side chain stereochemistry in the diagram is incorrect at both the methoxy and the next secondary hydroxyl. You can compare it to Zaninamivir and it is opposite and also does not match those structures already published in the chemistry literature. — Preceding unsigned comment added by 137.222.114.241 (talk) 09:08, 13 November 2015 (UTC)Reply