Talk:Interferon alfa-2b

I am not a medical “professional” but who I am is a barely surviving patient of Rebetron(Ribiviran & PegB alpha interferon) carried out for 13 mos under the completely nefarious and deception actions based solely on greed. In 2004 the useless FDA fined Schering Pharma $330Mil because instead of doing proper medical trials they knew they had no chance of completing because of the side effects of this “treatment” they instead paid like minded greedy doctors $500 for each person they put through this, which was ultimately a death sentence. Why aren’t any of these stories in your precious article? No doubt paid off by the same serpents that never spent a day behind bars. I’m currently suffering from Multiple Sclerosis that can’t decide just how many of the ways it’s tried to kill me, and will eventually succeed. I’m now 4” shorter after my thoracic spine collapsed(inoperably) from the severe irreversible osteoporosis caused by the destruction of the bone marrow in my entire skeletal system. Psoriasis, constant unrelenting pain that defies any pathetic 1-10 scale. To be able to feel your body being eaten alive by it’s own immune system caused ironically enough an “immunotherapy”,which is touted as the new great frontier of medicine. Just see how long that lasts when you honestly describe to the patient the many ways this treatment will kill and is a hell of a lot worse than what you’re currently ailing from. Remember this isn’t about anything but money and profit. The patients, well just who gives a damn, right? — Preceding unsigned comment added by Obadiah ets (talk • contribs) 19:25, 3 January 2021 (UTC)

Move discussion in progress

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Which clinical trials? Source?

This wikipedia article states that "The medication has also been used in clinical trials to treat patients with Severe acute respiratory syndrome coronavirus 2.". However, in the so-called source, I can't find any reference to an actual clinical trial about Interferon alfa-2B and SARS-COV-2 (maybe in the Chinese registry of Clinical Trials, but I can't find it). IN clinicaltrials.gov, I can only find trials on INterferon alfa-1b and SARS-COV-2 ( https://clinicaltrials.gov/ct2/results?cond=&term=interferon+alfa+coronavirus&cntry=&state=&city=&dist= ) except for prevention — Preceding unsigned comment added by 2A02:2788:1034:B45:C85D:877:D00F:8D62 (talk) 19:11, 30 March 2020 (UTC)

History

How could the interferons have been invented in 1980 when the virologists in Berlin Adlershof (GDR) were already working on them in the 1970s, see the vaccine for the English flu in 1973? The Cubans have their knowledge from the GDR, not from Schering. Unfortunately in 1992 the Treuhand destroyed all knowledge in Berlin Adlershof. — Preceding unsigned comment added by 2003:CF:E728:2E28:10C4:A147:2CB9:AD6D (talk) 13:49, 2 May 2020 (UTC)

Maybe that's true but the only way to produce large quantities is through recombinant expression, which I believe Weissmann's group figured out. "Invented" isn't really the right word anyway, because they exist naturally. My understanding is that "alpha" refers to the natural form and "alfa" refers to recombinant/drug form of interferons. Here's some more history accoridng to Nature, if anyone wants to dig deeper: [1]. Cuban scientists learned how to make recombinant interferon from american and finnish groups in the early '80s. Pelirojopajaro (talk) 09:50, 18 May 2020 (UTC)