Talk:Indatuximab ravtansine
Latest comment: 8 years ago by Rod57 in topic All genetic types of MM ?
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All genetic types of MM ? edit
multiple myeloma says
"A chromosomal translocation between the immunoglobulin heavy chain gene (on chromosome 14, locus q32) and an oncogene (often 11q13, 4p16.3, 6p21, 16q23 and 20q11[17]) is frequently observed in patients with multiple myeloma. This mutation results in dysregulation of the oncogene which is thought to be an important initiating event in the pathogenesis of myeloma.[citation needed] The result is proliferation of a plasma cell clone and genomic instability that leads to further mutations and translocations. The chromosome 14 abnormality is observed in about 50% of all cases of myeloma. Deletion of (parts of) chromosome 13 is also observed in about 50% of cases."
Its not clear if/how the chromosome changes relate to overexpression of CD138 that this drug targets. - Rod57 (talk) 00:57, 2 February 2016 (UTC)