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Tolcapone edit
This section needs rewriting to be more accessible to the pedestrian reader. —Preceding unsigned comment added by 1000Faces (talk • contribs) 01:24, 27 October 2007 (UTC)
Sites edit
I've heard that there are only 4 nuclei within the brain that are dopaminergic. Can you confirm and include this in the article? --1000Faces 01:26, 27 October 2007 (UTC)
Dopamine/L-Dopa Anti-depressant ? edit
" Precursor to the neurotransmitter dopamine, anti-depressant." L-Dopa isn't an anti-depressant and doesn't have enough anti-depressant properties to be describe as such. As I'm only a guess passing by, I'll just erase the ", anti-depressant." part. 21:59, 21 July 2008
Main article: Dopamine edit
Any arguments for or against the "Main article: Dopamine" link at the top of this page? I can't decide whether it's a good idea. Exercisephys (talk) 04:01, 26 October 2013 (UTC)
Acryonyms edit
This whole page is a mess of needless acronyms and synonyms. I'll hopefully remember to getting around to fixing it when it isn't so late, but I thought I'd post this here as a reminder to myself and others. Exercisephys (talk) 04:04, 26 October 2013 (UTC)
Disulfiram edit
Disulfiram is not an anti-craving agent, because it doesn't decrease craving for alcohol or any other drug. It prevents or deters a person from consuming alcohol, because it leads to disulfiram alcohol reaction, if alcohol is consumed along with disulfiram. Normally, alcohol is converted to acetaldehyde. Acetaldehyde is further converted to Acetyl CoA by aldehyde dehydrogenase. The above reaction occurs, because disulfiram blocks the enzyme aldehyde dehydrogenase and leads to accumulation of acetaldehde in the body. [1] Disulfiram may be useful as a deterrent drug for cocaine and other dopaminergic drugs by blocking the enzyme dopamine-β- hydroxylase. The excess dopamine results in increased anxiety, higher blood pressure, restlessness, and other unpleasant symptoms. Fear of having this symptoms prevents or deters a person from consuming cocaine or similar drug. Mukeshsamani (talk) 17:11, 20 January 2015 (UTC)
References
- ^ Krampe, Henning; Stawicki, Sabina; Wagner, Thilo; Bartels, Claudia; Aust, Carlotta; Ruther, Eckart; Poser, Wolfgang; Ehrenreich, Hannelore (2006). "Follow-up of 180 Alcoholic Patients for up to 7 Years After Outpatient Treatment: Impact of Alcohol Deterrents on Outcome". Alcoholism: Clinical and Experimental Research 30 (1): 86–95. doi:10.1111/j.1530-0277.2006.00013.x. PMID 16433735.