TXNL1

Thioredoxin-like protein 1 is a protein that in humans is encoded by the TXNL1 gene.

TXNL1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1GH2, 1WWY
Identifiers
Aliases	TXNL1, HEL-S-114, TRP32, TXL-1, TXNL, Txl, thioredoxin like 1
External IDs	OMIM: 603049; MGI: 1860078; HomoloGene: 3515; GeneCards: TXNL1; OMA:TXNL1 - orthologs
Gene location (Human) Chr. Chromosome 18 (human) Band 18q21.31 Start 56,597,209 bp End 56,651,600 bp
Gene location (Mouse) Chr. Chromosome 18 (mouse) Band 18|18 E1 Start 63,794,165 bp End 63,841,872 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in parotid gland endothelial cell hair follicle oral cavity right ventricle trabecular bone biceps brachii retinal pigment epithelium Epithelium of choroid plexus middle temporal gyrus Top expressed in endocardial cushion atrioventricular valve Paneth cell fossa condyle abdominal wall facial motor nucleus lacrimal gland dermis vas deferens More reference expression data BioGPS More reference expression data
Gene ontology Molecular function disulfide oxidoreductase activity oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor thioredoxin-disulfide reductase activity protein-disulfide reductase activity protein-disulfide reductase (NAD(P)) activity Cellular component cytoplasm proteasome complex nucleus cytosol Biological process cellular response to oxidative stress cell redox homeostasis cellular oxidant detoxification Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9352 53382 Ensembl ENSG00000091164 ENSMUSG00000024583 UniProt O43396 Q8CDN6 RefSeq (mRNA) NM_004786 NM_016792 RefSeq (protein) NP_004777 NP_058072 Location (UCSC) Chr 18: 56.6 – 56.65 Mb Chr 18: 63.79 – 63.84 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Further reading

• Miranda-Vizuete A, Spyrou G (2000). "Genomic structure and chromosomal localization of human thioredoxin-like protein gene (txl)". DNA Seq. 10 (6): 419–24. doi:10.3109/10425170009015613. hdl:10261/47456. PMID 10826702. S2CID 38627981.
• Jin J, Chen X, Zhou Y, et al. (2002). "Crystal structure of the catalytic domain of a human thioredoxin-like protein". Eur. J. Biochem. 269 (8): 2060–2068. doi:10.1046/j.1432-1033.2002.02844.x. PMID 11985582.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Gevaert K, Goethals M, Martens L, et al. (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nat. Biotechnol. 21 (5): 566–569. doi:10.1038/nbt810. PMID 12665801. S2CID 23783563.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–45. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Kim KY, Lee JW, Park MS, et al. (2006). "Expression of a thioredoxin-related protein-1 is induced by prostaglandin E(2)". Int. J. Cancer. 118 (7): 1670–1679. doi:10.1002/ijc.21572. PMID 16231315. S2CID 21916723.
• Guo D, Han J, Adam BL, et al. (2005). "Proteomic analysis of SUMO4 substrates in HEK293 cells under serum starvation-induced stress". Biochem. Biophys. Res. Commun. 337 (4): 1308–1318. doi:10.1016/j.bbrc.2005.09.191. PMID 16236267.
• Jiménez A, Pelto-Huikko M, Gustafsson JA, Miranda-Vizuete A (2006). "Characterization of human thioredoxin-like-1: potential involvement in the cellular response against glucose deprivation". FEBS Lett. 580 (3): 960–967. doi:10.1016/j.febslet.2006.01.025. hdl:10261/46508. PMID 16438969. S2CID 18655983.