Tetraspanin-6 is a protein that in humans is encoded by the TSPAN6 gene.[5][6]

TSPAN6
Identifiers
AliasesTSPAN6, T245, TM4SF6, TSPAN-6, tetraspanin 6
External IDsOMIM: 300191; MGI: 1926264; HomoloGene: 20700; GeneCards: TSPAN6; OMA:TSPAN6 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001278740
NM_001278741
NM_001278742
NM_001278743
NM_003270

NM_019656

RefSeq (protein)

NP_001265669
NP_001265670
NP_001265671
NP_001265672
NP_003261

n/a

Location (UCSC)Chr X: 100.63 – 100.64 MbChr X: 132.79 – 132.8 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein and is highly similar in sequence to the transmembrane 4 superfamily member 2. The use of alternate polyadenylation sites has been found for this gene.[6]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000000003Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000067377Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Maeda K, Matsuhashi S, Hori K, Xin Z, Mukai T, Tabuchi K, Egashira M, Niikawa N (Dec 1998). "Cloning and characterization of a novel human gene, TM4SF6, encoding a protein belonging to the transmembrane 4 superfamily, and mapped to Xq22". Genomics. 52 (2): 240–2. doi:10.1006/geno.1998.5415. PMID 9782095.
  6. ^ a b "Entrez Gene: TSPAN6 tetraspanin 6".

Further reading

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