TSPAN3

Tetraspanin-3 is a protein that in humans is encoded by the TSPAN3 gene.

TSPAN3
Identifiers
Aliases	TSPAN3, TM4-A, TM4SF8, TSPAN-3, tetraspanin 3
External IDs	OMIM: 613134; MGI: 1928098; HomoloGene: 21168; GeneCards: TSPAN3; OMA:TSPAN3 - orthologs
Gene location (Human) Chr. Chromosome 15 (human) Band 15q24.3 Start 77,041,404 bp End 77,083,984 bp
Gene location (Mouse) Chr. Chromosome 9 (mouse) Band 9|9 B Start 56,039,009 bp End 56,072,761 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in bronchial epithelial cell mucosa of sigmoid colon ventricular zone rectum corpus epididymis beta cell caput epididymis palpebral conjunctiva right uterine tube external globus pallidus Top expressed in vestibular sensory epithelium Epithelium of choroid plexus nucleus of stria terminalis central gray substance of midbrain ventral tegmental area right kidney left colon saccule dorsomedial hypothalamic nucleus superior colliculus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function molecular function Cellular component integral component of membrane integral component of plasma membrane extracellular exosome membrane Biological process cell surface receptor signaling pathway biological process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10099 56434 Ensembl ENSG00000140391 ENSMUSG00000032324 UniProt O60637 Q9QY33 RefSeq (mRNA) NM_198902 NM_001168412 NM_005724 NM_019793 RefSeq (protein) NP_001161884 NP_005715 NP_944492 NP_062767 Location (UCSC) Chr 15: 77.04 – 77.08 Mb Chr 9: 56.04 – 56.07 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains.

The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. The use of alternate polyadenylation sites has been found for this gene. Two alternative transcripts encoding different isoforms have been described.

Further reading

• Berditchevski F (2002). "Complexes of tetraspanins with integrins: more than meets the eye". J. Cell Sci. 114 (Pt 23): 4143–51. doi:10.1242/jcs.114.23.4143. PMID 11739647.
• Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Todd SC, Doctor VS, Levy S (1998). "Sequences and expression of six new members of the tetraspanin/TM4SF family". Biochim. Biophys. Acta. 1399 (1): 101–4. doi:10.1016/s0167-4781(98)00087-6. PMID 9714763.
• Wu YJ, Noguchi CT (1991). "Activation of globin gene expression by cDNAs from induced K562 cells. Evidence for involvement of ferritin in globin gene expression". J. Biol. Chem. 266 (26): 17566–72. doi:10.1016/S0021-9258(19)47409-7. PMID 1840594.

External links

• TSPAN3 human gene location in the UCSC Genome Browser.
• TSPAN3 human gene details in the UCSC Genome Browser.