TRA2A

Transformer-2 protein homolog alpha is a protein that in humans is encoded by the TRA2A gene.

TRA2A
Identifiers
Aliases	TRA2A, AWMS1, HSU53209, transformer 2 alpha homolog
External IDs	OMIM: 602718 MGI: 1933972 HomoloGene: 40866 GeneCards: TRA2A
Gene location (Human) Chr. Chromosome 7 (human) Band 7p15.3 Start 23,504,780 bp End 23,532,041 bp
Gene location (Mouse) Chr. Chromosome 6 (mouse) Band 6|6 B2.3 Start 49,220,858 bp End 49,240,967 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right uterine tube ganglionic eminence canal of the cervix sural nerve right lobe of thyroid gland vagina skin of abdomen left uterine tube minor salivary glands left lobe of thyroid gland Top expressed in pineal gland abdominal wall maxillary prominence dermis superior cervical ganglion ganglionic eminence conjunctival fornix cumulus cell trigeminal ganglion medial ganglionic eminence More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleic acid binding RNA binding Cellular component nucleolus intracellular membrane-bounded organelle nucleus ribonucleoprotein complex Biological process mRNA splicing, via spliceosome mRNA processing RNA splicing positive regulation of mRNA splicing, via spliceosome Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 29896 101214 Ensembl ENSG00000164548 ENSMUSG00000029817 UniProt Q13595 Q6PFR5 RefSeq (mRNA) NM_001282757 NM_001282758 NM_001282759 NM_013293 NM_001362759 NM_001362760 NM_001362761 NM_198102 NM_001347209 NM_001362188 RefSeq (protein) NP_001269686 NP_001269687 NP_001269688 NP_037425 NP_001349688 NP_001349689 NP_001349690 n/a Location (UCSC) Chr 7: 23.5 – 23.53 Mb Chr 6: 49.22 – 49.24 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

This gene is a member of the transformer 2 homolog family and encodes a protein with two RS domains and an RRM (RNA recognition motif) domain. This phosphorylated nuclear protein binds to specific RNA sequences and plays a role in the regulation of pre-mRNA splicing. Several alternatively spliced transcript variants of this gene have been described; however, the full-length nature of some of these variants has not been determined.

Further reading

• Sanger Centre T, Washington University Genome Sequencing Cente T (1999). "Toward a complete human genome sequence". Genome Res. 8 (11): 1097–108. doi:10.1101/gr.8.11.1097. PMID 9847074.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Matsuda A, Suzuki Y, Honda G, et al. (2003). "Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways". Oncogene. 22 (21): 3307–18. doi:10.1038/sj.onc.1206406. PMID 12761501.
• Shin C, Feng Y, Manley JL (2004). "Dephosphorylated SRp38 acts as a splicing repressor in response to heat shock". Nature. 427 (6974): 553–8. Bibcode:2004Natur.427..553S. doi:10.1038/nature02288. PMID 14765198. S2CID 4423246.
• Jin J, Smith FD, Stark C, et al. (2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization". Curr. Biol. 14 (16): 1436–50. doi:10.1016/j.cub.2004.07.051. PMID 15324660. S2CID 2371325.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Gevaert K, Staes A, Van Damme J, et al. (2006). "Global phosphoproteome analysis on human HepG2 hepatocytes using reversed-phase diagonal LC". Proteomics. 5 (14): 3589–99. doi:10.1002/pmic.200401217. PMID 16097034. S2CID 895879.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.