TNS1

Tensin-1 is a protein that in humans is encoded by the TNS1 gene.

TNS1
Identifiers
Aliases	TNS1, MST091, MST122, MST127, MSTP122, MSTP127, MXRA6, PPP1R155, TNS, MSTP091, tensin 1
External IDs	OMIM: 600076 MGI: 104552 HomoloGene: 11219 GeneCards: TNS1
Gene location (Human) Chr. Chromosome 2 (human) Band 2q35 Start 217,799,789 bp End 218,002,995 bp
Gene location (Mouse) Chr. Chromosome 1 (mouse) Band 1 C3|1 38.17 cM Start 73,949,390 bp End 74,163,608 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in saphenous vein urethra lower lobe of lung seminal vesicula right coronary artery popliteal artery nipple visceral pleura gastric mucosa synovial joint Top expressed in ascending aorta aortic valve interventricular septum right lung left lung right lung lobe left lung lobe myocardium of ventricle brown adipose tissue ankle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function actin binding protein binding RNA binding Cellular component cytoplasm cell-substrate junction cell surface cell junction cytoskeleton focal adhesion Biological process cell-substrate junction assembly fibroblast migration Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7145 21961 Ensembl ENSG00000079308 ENSMUSG00000055322 UniProt Q9HBL0 Q0VG54 n/a RefSeq (mRNA) NM_001308022 NM_001308023 NM_022648 NM_001289895 NM_027884 NM_177169 RefSeq (protein) NP_001294951 NP_001294952 NP_072174 NP_001294951.1 NP_001294952.1 n/a Location (UCSC) Chr 2: 217.8 – 218 Mb Chr 1: 73.95 – 74.16 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

The protein encoded by this gene localizes to focal adhesions, regions of the plasma membrane where the cell attaches to the extracellular matrix. This protein crosslinks actin filaments and contains a Src homology 2 (SH2) domain, which is often found in molecules involved in signal transduction. This protein is a substrate of calpain II. A second transcript from this gene has been described, but its full length nature has not been determined.

External links

• TNS1 Archived 2011-07-22 at the Wayback Machine Info with links in the Cell Migration Gateway Archived 2014-12-11 at the Wayback Machine

Further reading

• Jankowski SA, Gumucio DL (1996). "Genes for tensin, villin and desmin are linked on mouse chromosome 1" (PDF). Mamm. Genome. 6 (10): 744–5. doi:10.1007/BF00354299. hdl:2027.42/47016. PMID 8563175. S2CID 22316923.
• Salgia R, Pisick E, Sattler M, et al. (1996). "p130CAS forms a signaling complex with the adapter protein CRKL in hematopoietic cells transformed by the BCR/ABL oncogene". J. Biol. Chem. 271 (41): 25198–203. doi:10.1074/jbc.271.41.25198. PMID 8810278.
• Dias Neto E, Correa RG, Verjovski-Almeida S, et al. (2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491–6. Bibcode:2000PNAS...97.3491D. doi:10.1073/pnas.97.7.3491. PMC 16267. PMID 10737800.
• Katz BZ, Zohar M, Teramoto H, et al. (2000). "Tensin can induce JNK and p38 activation". Biochem. Biophys. Res. Commun. 272 (3): 717–20. doi:10.1006/bbrc.2000.2853. PMID 10860821.
• Chen H, Ishii A, Wong WK, et al. (2001). "Molecular characterization of human tensin". Biochem. J. 351 Pt 2 (2): 403–11. doi:10.1042/0264-6021:3510403. PMC 1221376. PMID 11023826.
• Benzing T, Gerke P, Höpker K, et al. (2001). "Nephrocystin interacts with Pyk2, p130(Cas), and tensin and triggers phosphorylation of Pyk2". Proc. Natl. Acad. Sci. U.S.A. 98 (17): 9784–9. Bibcode:2001PNAS...98.9784B. doi:10.1073/pnas.171269898. PMC 55530. PMID 11493697.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Yamashita M, Horikoshi S, Asanuma K, et al. (2004). "Tensin is potentially involved in extracellular matrix production in mesangial cells". Histochem. Cell Biol. 121 (3): 245–54. doi:10.1007/s00418-004-0626-8. PMID 14991332. S2CID 5634607.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
• Eto M, Kirkbride J, Elliott E, et al. (2007). "Association of the tensin N-terminal protein-tyrosine phosphatase domain with the alpha isoform of protein phosphatase-1 in focal adhesions". J. Biol. Chem. 282 (24): 17806–15. doi:10.1074/jbc.M700944200. PMID 17435217.