TNKS1BP1

182 kDa tankyrase-1-binding protein is an enzyme that in humans is encoded by the TNKS1BP1 gene.

TNKS1BP1
Identifiers
Aliases	TNKS1BP1, TAB182, tankyrase 1 binding protein 1
External IDs	OMIM: 607104; MGI: 2446193; HomoloGene: 14117; GeneCards: TNKS1BP1; OMA:TNKS1BP1 - orthologs
Gene location (Human) Chr. Chromosome 11 (human) Band 11q12.1 Start 57,299,638 bp End 57,324,952 bp
Gene location (Mouse) Chr. Chromosome 2 (mouse) Band 2|2 D Start 84,878,366 bp End 84,903,392 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gastric mucosa skin of abdomen skin of leg ectocervix canal of the cervix body of stomach minor salivary glands right coronary artery right lobe of liver upper lobe of left lung Top expressed in lip ankle joint dentate gyrus of hippocampal formation granule cell esophagus gastrula corneal stroma stomach primary visual cortex lacrimal gland lactiferous gland More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding enzyme binding ankyrin repeat binding cadherin binding protein-containing complex binding Cellular component chromosome CCR4-NOT complex cytosol cytoskeleton nucleus cytoplasm Biological process nuclear-transcribed mRNA poly(A) tail shortening telomere maintenance via telomerase DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest double-strand break repair positive regulation of peptidyl-threonine phosphorylation positive regulation of protein autophosphorylation positive regulation of peptidyl-serine phosphorylation cellular response to ionizing radiation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 85456 228140 Ensembl ENSG00000149115 ENSMUSG00000033955 UniProt Q9C0C2 P58871 RefSeq (mRNA) NM_033396 NM_001081260 RefSeq (protein) NP_203754 NP_001074729 Location (UCSC) Chr 11: 57.3 – 57.32 Mb Chr 2: 84.88 – 84.9 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Interactions

TNKS1BP1 has been shown to interact with TNKS.

Further reading

• Nakajima D, Okazaki N, Yamakawa H, Kikuno R, Ohara O, Nagase T (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Res. 9 (3): 99–106. doi:10.1093/dnares/9.3.99. PMID 12168954.
• Nagase T, Kikuno R, Hattori A, Kondo Y, Okumura K, Ohara O (2001). "Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (6): 347–55. doi:10.1093/dnares/7.6.347. PMID 11214970.
• Sbodio JI, Chi NW (2002). "Identification of a tankyrase-binding motif shared by IRAP, TAB182, and human TRF1 but not mouse TRF1. NuMA contains this RXXPDG motif and is a novel tankyrase partner". J. Biol. Chem. 277 (35): 31887–92. doi:10.1074/jbc.M203916200. PMID 12080061.
• Jikuya H, Takano J, Kikuno R, Hirosawa M, Nagase T, Nomura N, Ohara O (2003). "Characterization of long cDNA clones from human adult spleen. II. The complete sequences of 81 cDNA clones". DNA Res. 10 (1): 49–57. doi:10.1093/dnares/10.1.49. PMID 12693554.
• Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
• Ballif BA, Villén J, Beausoleil SA, Schwartz D, Gygi SP (2005). "Phosphoproteomic analysis of the developing mouse brain". Mol. Cell. Proteomics. 3 (11): 1093–101. doi:10.1074/mcp.M400085-MCP200. PMID 15345747.
• Seimiya H, Muramatsu Y, Ohishi T, Tsuruo T (2005). "Tankyrase 1 as a target for telomere-directed molecular cancer therapeutics". Cancer Cell. 7 (1): 25–37. doi:10.1016/j.ccr.2004.11.021. PMID 15652747.
• Chang P, Coughlin M, Mitchison TJ (2006). "Tankyrase-1 polymerization of poly(ADP-ribose) is required for spindle structure and function". Nat. Cell Biol. 7 (11): 1133–9. doi:10.1038/ncb1322. PMID 16244666. S2CID 12416419.
• Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.
• Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
• Gelmini S, Quattrone S, Malentacchi F, Villari D, Travaglini F, Giannarini G, Della Melina A, Pazzagli M, Nicita G, Selli C, Orlando C (2007). "Tankyrase-1 mRNA expression in bladder cancer and paired urine sediment: preliminary experience". Clin. Chem. Lab. Med. 45 (7): 862–6. doi:10.1515/CCLM.2007.133. PMID 17617028. S2CID 22726749.