TNFAIP8

Tumor necrosis factor, alpha-induced protein 8 is a protein that in humans is encoded by the TNFAIP8 gene. It is preferentially expressed in human immune cell types.

TNFAIP8
Identifiers
Aliases	TNFAIP8, GG2-1, MDC-3.13, NDED, SCC-S2, SCCS2, TNF alpha induced protein 8
External IDs	OMIM: 612111; MGI: 2147191; HomoloGene: 8649; GeneCards: TNFAIP8; OMA:TNFAIP8 - orthologs
Gene location (Human) Chr. Chromosome 5 (human) Band 5q23.1 Start 119,268,692 bp End 119,399,688 bp
Gene location (Mouse) Chr. Chromosome 18 (mouse) Band 18|18 D1 Start 50,112,494 bp End 50,240,240 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in cartilage tissue epithelium of nasopharynx appendix bone marrow white blood cell mononuclear cell monocyte lymph node bone marrow cells trabecular bone Top expressed in gastrula right kidney granulocyte decidua thymus human kidney primary oocyte spleen conjunctival fornix myocardium of ventricle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function cysteine-type endopeptidase inhibitor activity involved in apoptotic process protein binding Cellular component cytoplasm nucleoplasm Biological process negative regulation of apoptotic process apoptotic process negative regulation of cysteine-type endopeptidase activity involved in apoptotic process positive regulation of apoptotic process regulation of apoptotic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 25816 106869 Ensembl ENSG00000145779 ENSMUSG00000062210 UniProt O95379 Q921Z5 RefSeq (mRNA) NM_014350 NM_001077654 NM_001286813 NM_001286814 NM_001286815 NM_001286817 NM_001177759 NM_001177760 NM_134131 NM_001360935 RefSeq (protein) NP_001071122 NP_001273742 NP_001273743 NP_001273744 NP_001273746 NP_055165 NP_001171230 NP_001171231 NP_598892 NP_001347864 Location (UCSC) Chr 5: 119.27 – 119.4 Mb Chr 18: 50.11 – 50.24 Mb PubMed search
Wikidata
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Further reading

• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556.
• Kumar D, Gokhale P, Broustas C, et al. (2004). "Expression of SCC-S2, an antiapoptotic molecule, correlates with enhanced proliferation and tumorigenicity of MDA-MB 435 cells". Oncogene. 23 (2): 612–6. doi:10.1038/sj.onc.1207123. PMID 14724590.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.