Transmembrane protease, serine 11D is an enzyme that in humans is encoded by the TMPRSS11D gene.[4][5][6]

AliasesTMPRSS11D, HAT, transmembrane protease, serine 11D, transmembrane serine protease 11D
External IDsOMIM: 605369 MGI: 2385221 HomoloGene: 74519 GeneCards: TMPRSS11D
Gene location (Human)
Chromosome 4 (human)
Chr.Chromosome 4 (human)[1]
Chromosome 4 (human)
Genomic location for TMPRSS11D
Genomic location for TMPRSS11D
Band4q13.2Start67,820,876 bp[1]
End67,884,002 bp[1]
RNA expression pattern
PBB GE TMPRSS11D 207602 at fs.png

PBB GE TMPRSS11D gnf1h04254 s at fs.png
More reference expression data
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC)Chr 4: 67.82 – 67.88 Mbn/a
PubMed search[2][3]
View/Edit HumanView/Edit Mouse

This gene encodes a trypsin-like serine protease released from the submucosal serous glands onto mucous membrane. It is a type II integral membrane protein and has 29-38% identity in the sequence of the catalytic region with human hepsin, enteropeptidase, acrosin, and mast cell tryptase. The noncatalytic region has little similarity to other known proteins. This protein may play some biological role in the host defense system on the mucous membrane independently of or in cooperation with other substances in airway mucous or bronchial secretions.[6]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000153802 - Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ Yamaoka K, Masuda K, Ogawa H, Takagi K, Umemoto N, Yasuoka S (Jun 1998). "Cloning and characterization of the cDNA for human airway trypsin-like protease". J Biol Chem. 273 (19): 11895–901. doi:10.1074/jbc.273.19.11895. PMID 9565616.
  5. ^ Yasuoka S, Ohnishi T, Kawano S, Tsuchihashi S, Ogawara M, Masuda K, Yamaoka K, Takahashi M, Sano T (Apr 1997). "Purification, characterization, and localization of a novel trypsin-like protease found in the human airway". Am J Respir Cell Mol Biol. 16 (3): 300–8. doi:10.1165/ajrcmb.16.3.9070615. PMID 9070615.
  6. ^ a b "Entrez Gene: TMPRSS11D transmembrane protease, serine 11D".

Further readingEdit

External linksEdit

  • Overview of all the structural information available in the PDB for UniProt: Q8VHK8 (Mouse Transmembrane protease serine 11D) at the PDBe-KB.