TFB2M

Dimethyladenosine transferase 2; transcription factor B2, mitochondrial is an enzyme that in humans is encoded by the TFB2M gene.

TFB2M
Identifiers
Aliases	TFB2M, Hkp1, mtTFB2, transcription factor B2, mitochondrial
External IDs	OMIM: 607055; MGI: 107937; HomoloGene: 7362; GeneCards: TFB2M; OMA:TFB2M - orthologs
Gene location (Human) Chr. Chromosome 1 (human) Band 1q44 Start 246,540,561 bp End 246,566,261 bp
Gene location (Mouse) Chr. Chromosome 1 (mouse) Band 1 H4|1 83.56 cM Start 179,355,620 bp End 179,373,832 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte palpebral conjunctiva right adrenal gland right adrenal cortex biceps brachii tibia left adrenal gland right lobe of liver parietal pleura Skeletal muscle tissue of biceps brachii Top expressed in muscle of thigh quadriceps femoris muscle muscle tissue skeletal muscle tissue tail of embryo zygote renal cortex proximal tubule heart epiblast More reference expression data BioGPS More reference expression data
Gene ontology Molecular function methyltransferase activity transferase activity transcription coregulator activity rRNA methyltransferase activity rRNA (adenine-N6,N6-)-dimethyltransferase activity RNA binding Cellular component cell junction mitochondrial nucleoid mitochondrial matrix mitochondrion Biological process positive regulation of transcription, DNA-templated rRNA processing methylation mitochondrion organization regulation of transcription, DNA-templated rRNA methylation transcription, DNA-templated mitochondrial transcription transcription initiation from mitochondrial promoter rRNA modification Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 64216 15278 Ensembl ENSG00000162851 ENSMUSG00000026492 UniProt Q9H5Q4 Q3TL26 RefSeq (mRNA) NM_022366 NM_008249 NM_001331054 NM_001331055 RefSeq (protein) NP_071761 NP_001317983 NP_001317984 NP_032275 Location (UCSC) Chr 1: 246.54 – 246.57 Mb Chr 1: 179.36 – 179.37 Mb PubMed search
Wikidata
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This protein is a transcription initiation factor for the mitochondrial RNA polymerase, POLRMT. Its paralog TFB1M can perform a similar function, but only in vitro.

Further reading

• Falkenberg M, Gaspari M, Rantanen A, et al. (2002). "Mitochondrial transcription factors B1 and B2 activate transcription of human mtDNA". Nat. Genet. 31 (3): 289–94. doi:10.1038/ng909. PMID 12068295. S2CID 11164308.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Rantanen A, Gaspari M, Falkenberg M, et al. (2003). "Characterization of the mouse genes for mitochondrial transcription factors B1 and B2". Mamm. Genome. 14 (1): 1–6. doi:10.1007/s00335-002-2218-z. PMID 12532263. S2CID 25379746.
• McCulloch V, Shadel GS (2003). "Human mitochondrial transcription factor B1 interacts with the C-terminal activation region of h-mtTFA and stimulates transcription independently of its RNA methyltransferase activity". Mol. Cell. Biol. 23 (16): 5816–24. doi:10.1128/MCB.23.16.5816-5824.2003. PMC 166325. PMID 12897151.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Gaspari M, Falkenberg M, Larsson NG, Gustafsson CM (2005). "The mitochondrial RNA polymerase contributes critically to promoter specificity in mammalian cells". EMBO J. 23 (23): 4606–14. doi:10.1038/sj.emboj.7600465. PMC 533051. PMID 15526033.
• Gleyzer N, Vercauteren K, Scarpulla RC (2005). "Control of mitochondrial transcription specificity factors (TFB1M and TFB2M) by nuclear respiratory factors (NRF-1 and NRF-2) and PGC-1 family coactivators". Mol. Cell. Biol. 25 (4): 1354–66. doi:10.1128/MCB.25.4.1354-1366.2005. PMC 548005. PMID 15684387.
• Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.
• Cotney J, Shadel GS (2007). "Evidence for an early gene duplication event in the evolution of the mitochondrial transcription factor B family and maintenance of rRNA methyltransferase activity in human mtTFB1 and mtTFB2". J. Mol. Evol. 63 (5): 707–17. doi:10.1007/s00239-006-0075-1. PMID 17031457. S2CID 7673903.
• Cotney J, Wang Z, Shadel GS (2007). "Relative abundance of the human mitochondrial transcription system and distinct roles for h-mtTFB1 and h-mtTFB2 in mitochondrial biogenesis and gene expression". Nucleic Acids Res. 35 (12): 4042–54. doi:10.1093/nar/gkm424. PMC 1919481. PMID 17557812.