Transcription elongation factor A protein 1 is a protein that in humans is encoded by the TCEA1 gene.[5][6][7]

TCEA1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesTCEA1, GTF2S, SII, TCEA, TF2S, TFIIS, transcription elongation factor A1
External IDsOMIM: 601425; MGI: 1196624; HomoloGene: 55984; GeneCards: TCEA1; OMA:TCEA1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_006756
NM_201437

NM_001159750
NM_001159751
NM_011541

RefSeq (protein)

NP_006747
NP_958845

NP_001153222
NP_001153223
NP_035671

Location (UCSC)Chr 8: 53.97 – 54.02 MbChr 1: 4.93 – 4.97 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

In other organisms, this gene is better known as transcription elongation factor II S (TFIIS). It mainly helps to resolve backtracked elongation complexes by inducing a cut in the RNAP active site, so reaction becomes possible again. It is also found in the eukaryotic transcription preinitiation complex.[8] A homolog in archaea performs the same main task, while bacteria use the non-homologous Gre.[9]

Interactions

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TCEA1 has been shown to interact with GTF2H1[10][11] and POLR2A.[10][11][12]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000187735Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000033813Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ DiMarco SP, Glover TW, Miller DE, Reines D, Warren ST (August 1996). "Transcription elongation factor SII (TCEA) maps to human chromosome 3p22 --> p21.3". Genomics. 36 (1): 185–8. doi:10.1006/geno.1996.0443. PMID 8812434.
  6. ^ Park H, Baek K, Jeon C, Agarwal K, Yoo O (February 1994). "Characterization of the gene encoding the human transcriptional elongation factor TFIIS". Gene. 139 (2): 263–7. doi:10.1016/0378-1119(94)90767-6. PMID 8112616.
  7. ^ "Entrez Gene: TCEA1 transcription elongation factor A (SII), 1".
  8. ^ Kim B, Nesvizhskii AI, Rani PG, Hahn S, Aebersold R, Ranish JA (October 2007). "The transcription elongation factor TFIIS is a component of RNA polymerase II preinitiation complexes". Proceedings of the National Academy of Sciences of the United States of America. 104 (41): 16068–73. Bibcode:2007PNAS..10416068K. doi:10.1073/pnas.0704573104. PMC 2042163. PMID 17913884.
  9. ^ Robinson NP, Fouqueau T, Blombach F, Cackett G, Carty AE, Matelska DM, Ofer S, Pilotto S, Phung DK, Werner F (14 December 2018). "The cutting edge of archaeal transcription". Emerging Topics in Life Sciences. 2 (4): 517–533. doi:10.1042/ETLS20180014. PMC 7289017. PMID 33525828.
  10. ^ a b Archambault J, Pan G, Dahmus GK, Cartier M, Marshall N, Zhang S, et al. (October 1998). "FCP1, the RAP74-interacting subunit of a human protein phosphatase that dephosphorylates the carboxyl-terminal domain of RNA polymerase IIO". The Journal of Biological Chemistry. 273 (42): 27593–601. doi:10.1074/jbc.273.42.27593. PMID 9765293.
  11. ^ a b Pan G, Aso T, Greenblatt J (September 1997). "Interaction of elongation factors TFIIS and elongin A with a human RNA polymerase II holoenzyme capable of promoter-specific initiation and responsive to transcriptional activators". The Journal of Biological Chemistry. 272 (39): 24563–71. doi:10.1074/jbc.272.39.24563. PMID 9305922.
  12. ^ Kettenberger H, Armache KJ, Cramer P (August 2003). "Architecture of the RNA polymerase II-TFIIS complex and implications for mRNA cleavage". Cell. 114 (3): 347–57. doi:10.1016/S0092-8674(03)00598-1. hdl:11858/00-001M-0000-0015-8647-8. PMID 12914699. S2CID 17184533.

Further reading

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