Trace amine-associated receptor 9 is a protein that in humans is encoded by the TAAR9 gene .[ 5] [ 6]
TAAR9 is a member of a large family of rhodopsin G protein–coupled receptors (GPCRs, or GPRs). GPCRs contain 7 transmembrane domains and transduce extracellular signals through heterotrimeric G proteins .[supplied by OMIM][ 6] [ 7] [ 8]
TAAR9 gene deletion in rats leads to significantly decreased low-density lipoprotein cholesterol levels in the blood.[ 9]
^ a b c GRCh38: Ensembl release 89: ENSG00000237110 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000037424 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Lindemann L, Ebeling M, Kratochwil NA, Bunzow JR, Grandy DK, Hoener MC (March 2005). "Trace amine-associated receptors form structurally and functionally distinct subfamilies of novel G protein-coupled receptors". Genomics . 85 (3): 372–85. doi :10.1016/j.ygeno.2004.11.010 . PMID 15718104 . ^ a b "Entrez Gene: TAAR9 trace amine associated receptor 9" .^ Ferrero DM, Wacker D, Roque MA, Baldwin MW, Stevens RC, Liberles SD (July 2012). "Agonists for 13 trace amine-associated receptors provide insight into the molecular basis of odor selectivity" . ACS Chemical Biology . 7 (7): 1184–9. doi :10.1021/cb300111e . PMC 3401279 PMID 22545963 . ^ Liberles SD (October 2015). "Trace amine-associated receptors: ligands, neural circuits, and behaviors" . Current Opinion in Neurobiology . 34 : 1–7. doi :10.1016/j.conb.2015.01.001 . PMC 4508243 PMID 25616211 . ^ Murtazina RZ, Zhukov IS, Korenkova OM, Popova EA, Kuvarzin SR, Efimova EV, et al. (March 2021). "Genetic Deletion of Trace-Amine Associated Receptor 9 (TAAR9) in Rats Leads to Decreased Blood Cholesterol Levels" . International Journal of Molecular Sciences . 22 (6): 2942. doi :10.3390/ijms22062942 PMC 7998418 PMID 33799339 .
Borowsky B, Adham N, Jones KA, Raddatz R, Artymyshyn R, Ogozalek KL, et al. (July 2001). "Trace amines: identification of a family of mammalian G protein-coupled receptors" . Proceedings of the National Academy of Sciences of the United States of America . 98 (16): 8966–71. Bibcode :2001PNAS...98.8966B . doi :10.1073/pnas.151105198 PMC 55357 PMID 11459929 . Vanti WB, Muglia P, Nguyen T, Cheng R, Kennedy JL, George SR, O'Dowd BF (November 2003). "Discovery of a null mutation in a human trace amine receptor gene". Genomics . 82 (5): 531–6. doi :10.1016/S0888-7543(03)00173-3 . PMID 14559210 .
This article incorporates text from the United States National Library of Medicine , which is in the public domain .
