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Surfactant protein D

Surfactant protein D, also known as SFTPD or SP-D, is a protein which in humans is encoded by the SFTPD gene.[5][6]

Protein SFTPD PDB 1b08.png
Available structures
PDBOrtholog search: PDBe RCSB
AliasesSFTPD, COLEC7, PSP-D, SFTP4, SP-D, surfactant protein D
External IDsOMIM: 178635 MGI: 109515 HomoloGene: 2272 GeneCards: SFTPD
Gene location (Human)
Chromosome 10 (human)
Chr.Chromosome 10 (human)[1]
Chromosome 10 (human)
Genomic location for SFTPD
Genomic location for SFTPD
Band10q22.3Start79,937,740 bp[1]
End79,982,614 bp[1]
RNA expression pattern
PBB GE SFTPD 214199 at fs.png
More reference expression data
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC)Chr 10: 79.94 – 79.98 MbChr 14: 41.17 – 41.19 Mb
PubMed search[3][4]
View/Edit HumanView/Edit Mouse

SFTPD is an innate immune system collectin.[7][8]


Surfactant protein D has been shown to interact with DMBT1,[9][10] and hemagglutinin of influenza A virus.[11] Post-translational modification of SP-D i.e. S-nitrosylation switches its function(,,

See alsoEdit


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000133661 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000021795 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Rust K, Grosso L, Zhang V, Chang D, Persson A, Longmore W, Cai GZ, Crouch E (October 1991). "Human surfactant protein D: SP-D contains a C-type lectin carbohydrate recognition domain". Arch. Biochem. Biophys. 290 (1): 116–26. doi:10.1016/0003-9861(91)90597-C. PMID 1898081.
  6. ^ Lu J, Willis AC, Reid KB (June 1992). "Purification, characterization and cDNA cloning of human lung surfactant protein D". Biochem. J. 284. 284 ( Pt 3): 795–802. PMC 1132609. PMID 1339284.
  7. ^ "Entrez Gene: SFTPD surfactant, pulmonary-associated protein D".
  8. ^ Brandt EB, Mingler MK, Stevenson MD, Wang N, Khurana Hershey GK, Whitsett JA, Rothenberg ME (May 2008). "Surfactant protein D alters allergic lung responses in mice and human subjects". J. Allergy Clin. Immunol. 121 (5): 1140–1147.e2. doi:10.1016/j.jaci.2008.02.011. PMC 4145593. PMID 18355911.
  9. ^ Tino MJ, Wright JR (April 1999). "Glycoprotein-340 binds surfactant protein-A (SP-A) and stimulates alveolar macrophage migration in an SP-A-independent manner". Am. J. Respir. Cell Mol. Biol. 20 (4): 759–68. doi:10.1165/ajrcmb.20.4.3439. PMID 10101009.
  10. ^ Holmskov U, Lawson P, Teisner B, Tornoe I, Willis AC, Morgan C, Koch C, Reid KB (May 1997). "Isolation and characterization of a new member of the scavenger receptor superfamily, glycoprotein-340 (gp-340), as a lung surfactant protein-D binding molecule". J. Biol. Chem. 272 (21): 13743–9. doi:10.1074/jbc.272.21.13743. PMID 9153228.
  11. ^ Goh, Boon Chong; Rynkiewicz, Michael J.; Cafarella, Tanya R.; White, Mitchell R.; Hartshorn, Kevan L.; Allen, Kimberly; Crouch, Erika C.; Calin, Oliviana; Seeberger, Peter H. (2013-11-13). "Molecular Mechanisms of Inhibition of Influenza by Surfactant Protein D Revealed by Large-Scale Molecular Dynamics Simulation". Biochemistry. 52 (47): 8527–8538. doi:10.1021/bi4010683. PMC 3927399. PMID 24224757.

External linksEdit

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