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A suppository is a solid dosage form that is inserted into the rectum (rectal suppository), vagina (vaginal suppository), or urethra (urethral suppository), where it dissolves or melts and exerts local or systemic effects. Suppositories are used to deliver medications that act both systemically and locally.

CompositionEdit

Several different ingredients can be used to form the base of a suppository: cocoa butter or a similar substitute, polyethylene glycol, hydrogels, and glycerinated gelatin. The type of material used depends on the type of suppository, the type of drug, and the conditions in which the suppository will be stored.[1]

Rectal suppositoriesEdit

 
Glycerin suppositories (laxative)

In 1991, Abd-El-Maeboud and his colleagues conducted a study on suppository insertion in The Lancet,[2] explaining that the "torpedo" shape helps the device to travel internally, increasing its efficacy. The findings of this single study have been challenged as there is insufficient evidence on which to base clinical practice.[3]

 
Four 500 mg paracetamol suppositories

Urethral suppositoriesEdit

Alprostadil pellets are urethral suppositories used for the treatment of severe erectile dysfunction. They are marketed under the name Muse in the United States of America.[4] Its use has diminished since the development of oral impotence medications.

See alsoEdit

NotesEdit

  1. ^ Troy, David B.; Beringer, Paul (2006). Remington: The Science and Practice of Pharmacy. Lippincott Williams & Wilkins. pp. 884–885. ISBN 9780781746731.
  2. ^ Abd-El-Maeboud, K. H.; T. El-Naggar; E. M. M. El-Hawi; S. A. R. Mahmoud; S. Abd-El-Hay (28 September 1991). "Rectal suppository: commonsense and mode of insertion". The Lancet. 338 (8770): 798–800. doi:10.1016/0140-6736(91)90676-G. PMID 1681170.
  3. ^ Bradshaw, Ann; Lynda Price (20 December 2006). "Rectal suppository insertion: the reliability of the evidence as a basis for nursing practice". Journal of Clinical Nursing. 16 (1): 98–103. doi:10.1111/j.1365-2702.2005.01519.x. PMID 17181671.
  4. ^ "Muse Suppository - Facts and Comparisons". Drugs.com. Retrieved 4 January 2013.

ReferencesEdit

  • Doyle, D., "Per Rectum: A History of Enemata", Journal of the Royal College of Physicians of Edinburgh, Vol.35, No.4, (December 2005), pp. 367–370.
  • Payer, L., "How Medical Practice Reflects National Culture", The Sciences, Vol.30, No.4, (July–August 1990), pp. 38–42.