Strictosidine beta-glucosidase

3α(S)-strictosidine β-glucosidase (EC 3.2.1.105) is an enzyme with systematic name strictosidine β-D-glucohydrolase.[1][2][3] It catalyses the following chemical reaction:

3α(S)-strictosidine β-glucosidase
Identifiers
EC no.3.2.1.105
CAS no.73379-57-4
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Search
PMCarticles
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NCBIproteins
strictosidine + H2O D-glucose + strictosidine aglycone

It belongs to the family of hydrolases, specifically those glycosidases that hydrolyse O- and S-glycosyl compounds. It participates in indole and ipecac alkaloid biosynthesis.

Strictosidine is a precursor of indole alkaloids.

References

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  1. ^ Hemscheidt T, Zenk MH (February 1980). "Glucosidases involved in indole alkaloid biosynthesis of Catharanthus cell cultures". FEBS Letters. 110 (2): 187–91. doi:10.1016/0014-5793(80)80069-X. PMID 6768587.
  2. ^ Luijendijk TJ, Stevens LH, Verpoorte R (1998). "Purification and characterisation of strictosidine β-D-glucosidase from Catharanthus roseus cell suspension cultures". Plant Physiol. Biochem. 36 (6): 419–425. doi:10.1016/S0981-9428(98)80205-2.
  3. ^ Barleben L, Ma X, Koepke J, Peng G, Michel H, Stöckigt J (February 2005). "Expression, purification, crystallization and preliminary X-ray analysis of strictosidine glucosidase, an enzyme initiating biosynthetic pathways to a unique diversity of indole alkaloid skeletons". Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics. 1747 (1): 89–92. doi:10.1016/j.bbapap.2004.09.026. PMID 15680242.
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