Steroidogenic enzyme

Steroidogenic enzymes are enzymes that are involved in steroidogenesis and steroid biosynthesis.[2][3][4][5] They are responsible for the biosynthesis of the steroid hormones, including sex steroids (androgens, estrogens, and progestogens) and corticosteroids (glucocorticoids and mineralocorticoids), as well as neurosteroids, from cholesterol.[3][4][5] Steroidogenic enzymes are most highly expressed in classical steroidogenic tissues, such as the testis, ovary, and adrenal cortex, but are also present in other tissues in the body.[3][4][5]

List of steroidogenic enzymesEdit

Steroid numbering.

See alsoEdit


  1. ^ Häggström, Mikael; Richfield, David (2014). "Diagram of the pathways of human steroidogenesis". WikiJournal of Medicine. 1 (1). doi:10.15347/wjm/2014.005.
  2. ^ Hanukoglu I (Dec 1992). "Steroidogenic enzymes: structure, function, and role in regulation of steroid hormone biosynthesis". The Journal of Steroid Biochemistry and Molecular Biology. 43 (8): 779–804. doi:10.1016/0960-0760(92)90307-5. PMID 22217824.
  3. ^ a b c Payne AH, Hales DB (2004). "Overview of steroidogenic enzymes in the pathway from cholesterol to active steroid hormones". Endocr. Rev. 25 (6): 947–70. doi:10.1210/er.2003-0030. PMID 15583024.
  4. ^ a b c Luu-The V, Labrie F (2010). "The intracrine sex steroid synthesis pathways". Prog. Brain Res. Progress in Brain Research. 181: 177–92. doi:10.1016/S0079-6123(08)81010-2. ISBN 9780444536174. PMID 20478438.
  5. ^ a b c Honour JW (2009). "Diagnosis of diseases of steroid hormone production, metabolism and action". J Clin Res Pediatr Endocrinol. 1 (5): 209–26. doi:10.4274/jcrpe.v1i5.209. PMC 3005746. PMID 21274298.
  6. ^ Guillemette C, Lévesque E, Harvey M, Bellemare J, Menard V (2010). "UGT genomic diversity: beyond gene duplication". Drug Metab. Rev. 42 (1): 24–44. doi:10.3109/03602530903210682. hdl:20.500.11794/10528. PMID 19857043.
  7. ^ William Fishman (2 December 2012). Metabolic Conjugation and Metabolic Hydrolysis, Volume II. Elsevier. pp. 1–. ISBN 978-0-323-14308-0.
  8. ^ a b Mueller JW, Gilligan LC, Idkowiak J, Arlt W, Foster PA (2015). "The Regulation of Steroid Action by Sulfation and Desulfation". Endocr. Rev. 36 (5): 526–63. doi:10.1210/er.2015-1036. PMC 4591525. PMID 26213785.