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Sodium calcium edetate

Sodium calcium edetate (sodium calcium EDTA), also known as edetate calcium disodium among other names, is a medication primarily used to treat lead poisoning.[1] This includes short term and long term lead poisoning.[2] For lead encephalopathy it is typically used together with dimercaprol.[2] It does not appear to be useful for tetraethyllead toxicity.[2] It is given by slow injection into a vein or into a muscle.[1]

Sodium calcium edetate
Sodium calcium edetate.svg
Clinical data
Trade namesCalcium disodium versenate, others
Other namesedetate calcium disodium, sodium calcium edetate
AHFS/Drugs.comMonograph
Pregnancy
category
  • US: B (No risk in non-human studies)
Routes of
administration
IV, IM
Drug classchelating agent
ATC code
Identifiers
CAS Number
PubChem CID
DrugBank
ChemSpider
E numberE385 (antioxidants, ...) Edit this at Wikidata
CompTox Dashboard (EPA)
ECHA InfoCard100.000.482 Edit this at Wikidata
Chemical and physical data
FormulaC10H12CaN2Na2O8
Molar mass374.270 g·mol−1
3D model (JSmol)

Common side effects include pain at the site of injection.[2] Other side effects may include kidney problems, diarrhea, fever, muscle pains, and low blood pressure.[1] Benefits when needed in pregnancy are likely greater than the risks.[2] Sodium calcium edetate is in the chelating agent family of medication.[2] It is a salt of edetate with two sodium and one calcium atoms.[3] It works by binding a number of heavy metals which allows them to leave the body in the urine.[2]

Sodium calcium edetate came into medical use in the United States in 1953.[2] It is on the World Health Organization's List of Essential Medicines, the most effective and safe medicines needed in a health system.[4] In the United States a course of treatment costs 50 to 100 USD as of 2015.[5] Edetate disodium is a different formulation which does not have the same effects.[2]

Medical usesEdit

The primarily use is to treat lead poisoning.[1] In lead toxicity it is an alternative to succimer.[2]

It may also be used for plutonium toxicity.[6]

HistoryEdit

Sodium calcium edetate came into medical use in the United States in 1953.[2]

ReferencesEdit

  1. ^ a b c d WHO Model Formulary 2008 (PDF). World Health Organization. 2009. p. X. ISBN 9789241547659. Archived (PDF) from the original on 13 December 2016. Retrieved 8 January 2017.
  2. ^ a b c d e f g h i j k "Edetate Calcium Disodium". The American Society of Health-System Pharmacists. Archived from the original on 16 January 2017. Retrieved 8 January 2017.
  3. ^ Kasture, Dr A. V. (2008). Pharmaceutical Chemistry - I. Pragati Books Pvt. Ltd. p. 16.11. ISBN 9788185790121. Archived from the original on 2017-01-16.
  4. ^ "WHO Model List of Essential Medicines (19th List)" (PDF). World Health Organization. April 2015. Archived (PDF) from the original on 13 December 2016. Retrieved 8 December 2016.
  5. ^ Hamilton, Richart (2015). Tarascon Pocket Pharmacopoeia 2015 Deluxe Lab-Coat Edition. Jones & Bartlett Learning. p. 471. ISBN 9781284057560.
  6. ^ Flanagan, Robert; Jones, Alison; Maynard, Robert L. (2003). Antidotes: Principles and Clinical Applications. CRC Press. p. 47. ISBN 9780203485071. Archived from the original on 2017-01-16.