Simelane is a surname. Notable people with the surname include:
- Constance Simelane, Swazi politician
- Israel Simelane, TV and Radio Producer, Eswatini
- David Thabo Simelane (born 1956), Swazi serial killer
- Eudy Simelane (1977–2008), South African footballer
- Lojiba Simelane of Swaziland, Swazi monarch
- Menzi Simelane, South African lawyer
- Musa Simelane (born 1974), Swazi boxer
- Mduduzi 'Magawugawu' Simelane, Politician, Eswatini
- Njabuliso Simelane (born 1979), Swazi footballer
- Somnjalose Simelane, Swazi monarch
- Tiffany Simelane (1988–2009), Swazi beauty queen
- Hlengiwe Lucia Simelane known as Lucia Simelane Ochan -Mrs Curve Globe 23 , Mrs South Africa Curve Globe 23, Mrs Africa Globe 2019, South Africa Beauty Queen, International Business Woman , Philanthropist, Social Entrepreneur & Activist and UN Global Award Honoree
- Bongekile Simelane (known as Babes Wodumo), South African Musician
Simelane may also refer to:
- Democratic Alliance v President of the Republic of South Africa and Others, a 2012 South African legal case nicknamed for one of the respondents, Menzi Simelane