Sepiapterin reductase (L-threo-7,8-dihydrobiopterin forming)

Sepiapterin reductase (L-threo-7,8-dihydrobiopterin forming) (EC 1.1.1.325) is an enzyme with systematic name L-threo-7,8-dihydrobiopterin:NADP+ oxidoreductase.[1][2] This enzyme catalyses the following chemical reaction

Sepiapterin reductase (L-threo-7,8-dihydrobiopterin forming)
Identifiers
EC no.1.1.1.325
CAS no.9059-48-7
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
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NCBIproteins
(1) L-threo-7,8-dihydrobiopterin + NADP+ sepiapterin + NADPH + H+
(2) L-threo-tetrahydrobiopterin + 2 NADP+ 6-pyruvoyl-5,6,7,8-tetrahydropterin + 2 NADPH + 2 H+

This bacterial (Chlorobium tepidum) enzyme catalyses the final step in the de novo synthesis of tetrahydrobiopterin from GTP.

References

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  1. ^ Cho SH, Na JU, Youn H, Hwang CS, Lee CH, Kang SO (June 1999). "Sepiapterin reductase producing L-threo-dihydrobiopterin from Chlorobium tepidum". The Biochemical Journal. 340 ( Pt 2): 497–503. doi:10.1042/0264-6021:3400497. PMC 1220277. PMID 10333495.
  2. ^ Supangat S, Choi YK, Park YS, Son D, Han CD, Lee KH (February 2005). "Expression, purification, crystallization and preliminary X-ray analysis of sepiapterin reductase from Chlorobium tepidum". Acta Crystallographica Section F. 61 (Pt 2): 202–4. doi:10.1107/S174430910403444X. PMC 1952253. PMID 16510994.
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