Semenogelin-1 is a protein that in humans is encoded by the SEMG1 gene.[3][4][5] The protein encoded by this gene is the predominant protein in semen. The encoded secreted protein is involved in the formation of a gel matrix that encases ejaculated spermatozoa. The prostate-specific antigen (PSA) protease processes this protein into smaller peptides, with each possibly having a separate function. The proteolysis process breaks down the gel matrix and allows the spermatozoa to move more freely. Two transcript variants encoding different isoforms have been found for this gene.[5]

SEMG1
Identifiers
AliasesSEMG1, CT103, SEMG, SGI, dJ172H20.2, Semenogelin I, semenogelin 1
External IDsOMIM: 182140; HomoloGene: 130511; GeneCards: SEMG1; OMA:SEMG1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_198139
NM_003007

n/a

RefSeq (protein)

NP_002998

n/a

Location (UCSC)Chr 20: 45.21 – 45.21 Mbn/a
PubMed search[2]n/a
Wikidata
View/Edit Human

See also

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References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000124233Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ Lilja H, Abrahamsson PA, Lundwall A (Mar 1989). "Semenogelin, the predominant protein in human semen. Primary structure and identification of closely related proteins in the male accessory sex glands and on the spermatozoa". J Biol Chem. 264 (3): 1894–900. doi:10.1016/S0021-9258(18)94272-9. PMID 2912989.
  4. ^ Jonsson M, Linse S, Frohm B, Lundwall A, Malm J (Apr 2005). "Semenogelins I and II bind zinc and regulate the activity of prostate-specific antigen". Biochem J. 387 (Pt 2): 447–53. doi:10.1042/BJ20041424. PMC 1134973. PMID 15563730.
  5. ^ a b "Entrez Gene: SEMG1 semenogelin I".

Further reading

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