Synapsin-3 is a protein that in humans is encoded by the SYN3 gene.[5][6]

SYN3
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesSYN3, synapsin III
External IDsOMIM: 602705; MGI: 1351334; HomoloGene: 68320; GeneCards: SYN3; OMA:SYN3 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001164495
NM_013722

RefSeq (protein)

NP_001157967
NP_038750

Location (UCSC)Chr 22: 32.51 – 33.06 MbChr 10: 86.06 – 86.5 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

This gene is a member of the synapsin gene family. Synapsins encode neuronal phosphoproteins which associate with the cytoplasmic surface of synaptic vesicles. Family members are characterized by common protein domains, and they are implicated in synaptogenesis and the modulation of neurotransmitter release, suggesting a potential role in several neuropsychiatric diseases. The protein encoded by this gene shares the synapsin family domain model, with domains A, C, and E exhibiting the highest degree of conservation. The protein contains a unique domain J, located between domains C and E. Based on this gene's localization to 22q12.3, a possible schizophrenia susceptibility locus, and the established neurobiological roles of the synapsins, this family member may represent a candidate gene for schizophrenia. The TIMP3 gene is located within an intron of this gene and is transcribed in the opposite direction. Alternative splicing of this gene results in six transcript variants; however, only two variants have been fully described.[6]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000185666Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000059602Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Kao HT, Porton B, Czernik AJ, Feng J, Yiu G, Haring M, Benfenati F, Greengard P (May 1998). "A third member of the synapsin gene family". Proc Natl Acad Sci U S A. 95 (8): 4667–72. Bibcode:1998PNAS...95.4667K. doi:10.1073/pnas.95.8.4667. PMC 22548. PMID 9539796.
  6. ^ a b "Entrez Gene: SYN3 synapsin III".

Further reading

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