SULT4A1

Sulfotransferase 4A1 is an enzyme that in humans is encoded by the SULT4A1 gene.

SULT4A1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1ZD1
Identifiers
Aliases	SULT4A1, BR-STL-1, BRSTL1, DJ388M5.3, NST, SULTX3, hBR-STL-1, sulfotransferase family 4A member 1
External IDs	OMIM: 608359; MGI: 1888971; HomoloGene: 49378; GeneCards: SULT4A1; OMA:SULT4A1 - orthologs
Gene location (Human) Chr. Chromosome 22 (human) Band 22q13.31 Start 43,824,509 bp End 43,862,513 bp
Gene location (Mouse) Chr. Chromosome 15 (mouse) Band 15|15 E2 Start 83,960,298 bp End 83,989,955 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right frontal lobe prefrontal cortex Brodmann area 9 middle temporal gyrus Brodmann area 10 right hemisphere of cerebellum primary visual cortex cingulate gyrus anterior cingulate cortex frontal pole Top expressed in medial dorsal nucleus medial vestibular nucleus superior frontal gyrus medial geniculate nucleus lateral geniculate nucleus primary visual cortex dentate gyrus of hippocampal formation granule cell deep cerebellar nuclei pontine nuclei primary motor cortex More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity sulfotransferase activity protein binding aryl sulfotransferase activity identical protein binding Cellular component cytoplasm cytosol Biological process sulfur compound metabolic process steroid metabolic process 3'-phosphoadenosine 5'-phosphosulfate metabolic process lipid metabolism biological process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 25830 29859 Ensembl ENSG00000130540 ENSMUSG00000018865 UniProt Q9BR01 P63046 RefSeq (mRNA) NM_014351 NM_176874 NM_013873 NM_001356515 RefSeq (protein) NP_055166 NP_038901 NP_001343444 Location (UCSC) Chr 22: 43.82 – 43.86 Mb Chr 15: 83.96 – 83.99 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

This gene encodes a member of the sulfotransferase family. The encoded protein is a brain-specific sulfotransferase believed to be involved in the metabolism of neurotransmitters. Polymorphisms in this gene may be associated with susceptibility to schizophrenia.

Further reading

• Weinshilboum RM, Otterness DM, Aksoy IA, et al. (1997). "Sulfation and sulfotransferases 1: Sulfotransferase molecular biology: cDNAs and genes". FASEB J. 11 (1): 3–14. doi:10.1096/fasebj.11.1.9034160. PMID 9034160. S2CID 3977677.
• Glatt H, Engelke CE, Pabel U, et al. (2000). "Sulfotransferases: genetics and role in toxicology". Toxicol. Lett. 112–113 (1–3): 341–8. doi:10.1016/S0378-4274(99)00214-3. PMID 10720750.
• Glatt H (2001). "Sulfotransferases in the bioactivation of xenobiotics". Chem. Biol. Interact. 129 (1–2): 141–70. Bibcode:2000CBI...129..141G. doi:10.1016/S0009-2797(00)00202-7. PMID 11154739.
• Glatt H, Boeing H, Engelke CE, et al. (2001). "Human cytosolic sulphotransferases: genetics, characteristics, toxicological aspects". Mutat. Res. 482 (1–2): 27–40. doi:10.1016/S0027-5107(01)00207-X. PMID 11535246.
• Dunham I, Shimizu N, Roe BA, et al. (1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. Bibcode:1999Natur.402..489D. doi:10.1038/990031. PMID 10591208.
• Sakakibara Y, Suiko M, Pai TG, et al. (2002). "Highly conserved mouse and human brain sulfotransferases: molecular cloning, expression, and functional characterization". Gene. 285 (1–2): 39–47. doi:10.1016/S0378-1119(02)00431-6. PMID 12039030.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Collins JE, Goward ME, Cole CG, et al. (2003). "Reevaluating human gene annotation: a second-generation analysis of chromosome 22". Genome Res. 13 (1): 27–36. doi:10.1101/gr.695703. PMC 430954. PMID 12529303.
• Liyou NE, Buller KM, Tresillian MJ, et al. (2004). "Localization of a brain sulfotransferase, SULT4A1, in the human and rat brain: an immunohistochemical study". J. Histochem. Cytochem. 51 (12): 1655–64. doi:10.1177/002215540305101209. PMID 14623933.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Collins JE, Wright CL, Edwards CA, et al. (2005). "A genome annotation-driven approach to cloning the human ORFeome". Genome Biol. 5 (10): R84. doi:10.1186/gb-2004-5-10-r84. PMC 545604. PMID 15461802.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Brennan MD, Condra J (2006). "Transmission disequilibrium suggests a role for the sulfotransferase-4A1 gene in schizophrenia". Am. J. Med. Genet. B Neuropsychiatr. Genet. 139 (1): 69–72. doi:10.1002/ajmg.b.30222. PMID 16152568. S2CID 8927459.
• Allali-Hassani A, Pan PW, Dombrovski L, et al. (2007). "Structural and chemical profiling of the human cytosolic sulfotransferases". PLOS Biol. 5 (5): e97. doi:10.1371/journal.pbio.0050097. PMC 1847840. PMID 17425406.