Syntaxin-7 is a protein that in humans is encoded by the STX7 gene.[5][6]

STX7
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesSTX7, syntaxin 7
External IDsOMIM: 603217; MGI: 1858210; HomoloGene: 37823; GeneCards: STX7; OMA:STX7 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_003569
NM_001326578
NM_001326579
NM_001326580

NM_016797
NM_001358563

RefSeq (protein)

NP_001313507
NP_001313508
NP_001313509
NP_003560

NP_058077
NP_001345492

Location (UCSC)Chr 6: 132.45 – 132.51 MbChr 10: 24.03 – 24.07 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

In melanocytic cells STX7 gene expression may be regulated by MITF.[7]

Interactions

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STX7 has been shown to interact with STX8,[8] VPS18,[9] Vesicle-associated membrane protein 8[8][10] and VPS11.[9]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000079950Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000019998Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Wang H, Frelin L, Pevsner J (October 1997). "Human syntaxin 7: a Pep12p/Vps6p homologue implicated in vesicle trafficking to lysosomes". Gene. 199 (1–2): 39–48. doi:10.1016/S0378-1119(97)00343-0. PMID 9358037.
  6. ^ "Entrez Gene: STX7 syntaxin 7".
  7. ^ Hoek KS, Schlegel NC, Eichhoff OM, Widmer DS, Praetorius C, Einarsson SO, Valgeirsdottir S, Bergsteinsdottir K, Schepsky A, Dummer R, Steingrimsson E (December 2008). "Novel MITF targets identified using a two-step DNA microarray strategy". Pigment Cell & Melanoma Research. 21 (6): 665–76. doi:10.1111/j.1755-148X.2008.00505.x. PMID 19067971. S2CID 24698373.
  8. ^ a b Antonin W, Holroyd C, Fasshauer D, Pabst S, Von Mollard GF, Jahn R (December 2000). "A SNARE complex mediating fusion of late endosomes defines conserved properties of SNARE structure and function". The EMBO Journal. 19 (23): 6453–64. doi:10.1093/emboj/19.23.6453. PMC 305878. PMID 11101518.
  9. ^ a b Kim BY, Krämer H, Yamamoto A, Kominami E, Kohsaka S, Akazawa C (August 2001). "Molecular characterization of mammalian homologues of class C Vps proteins that interact with syntaxin-7". The Journal of Biological Chemistry. 276 (31): 29393–402. doi:10.1074/jbc.M101778200. PMID 11382755.
  10. ^ Wade N, Bryant NJ, Connolly LM, Simpson RJ, Luzio JP, Piper RC, James DE (June 2001). "Syntaxin 7 complexes with mouse Vps10p tail interactor 1b, syntaxin 6, vesicle-associated membrane protein (VAMP)8, and VAMP7 in b16 melanoma cells". The Journal of Biological Chemistry. 276 (23): 19820–7. doi:10.1074/jbc.M010838200. PMID 11278762.

Further reading

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