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Dolichyl-diphosphooligosaccharide—protein glycosyltransferase subunit STT3B is an enzyme that in humans is encoded by the STT3B gene.[5][6][7]

STT3B
Identifiers
AliasesSTT3B, CDG1X, SIMP, STT3-B, catalytic subunit of the oligosaccharyltransferase complex
External IDsMGI: 1915542 HomoloGene: 7387 GeneCards: STT3B
Gene location (Human)
Chromosome 3 (human)
Chr.Chromosome 3 (human)[1]
Chromosome 3 (human)
Genomic location for STT3B
Genomic location for STT3B
Band3p23Start31,532,638 bp[1]
End31,637,622 bp[1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_178862

NM_024222

RefSeq (protein)

NP_849193

NP_077184

Location (UCSC)Chr 3: 31.53 – 31.64 MbChr 9: 115.24 – 115.31 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Contents

FunctionEdit

The SIMP protein contains a highly immunogenic minor histocompatibility antigen epitope of 9 amino acids, B6(dom1). Like ITM1 (MIM 601134), SIMP is homologous to yeast STT3, an oligosaccharyltransferase essential for cell proliferation (McBride et al., 2002).[supplied by OMIM][7]

See alsoEdit

ReferencesEdit

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000163527 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000032437 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:".
  4. ^ "Mouse PubMed Reference:".
  5. ^ Kelleher DJ, Karaoglu D, Mandon EC, Gilmore R (July 2003). "Oligosaccharyltransferase isoforms that contain different catalytic STT3 subunits have distinct enzymatic properties". Molecular Cell. 12 (1): 101–11. doi:10.1016/S1097-2765(03)00243-0. PMID 12887896.
  6. ^ McBride K, Baron C, Picard S, Martin S, Boismenu D, Bell A, Bergeron J, Perreault C (November 2002). "The model B6(dom1) minor histocompatibility antigen is encoded by a mouse homolog of the yeast STT3 gene". Immunogenetics. 54 (8): 562–9. doi:10.1007/s00251-002-0502-4. PMID 12439619.
  7. ^ a b "Entrez Gene: STT3B STT3, subunit of the oligosaccharyltransferase complex, homolog B (S. cerevisiae)".

Further readingEdit

  • Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (November 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
  • Otsuki T, Ota T, Nishikawa T, Hayashi K, Suzuki Y, Yamamoto J, Wakamatsu A, Kimura K, Sakamoto K, Hatano N, Kawai Y, Ishii S, Saito K, Kojima S, Sugiyama T, Ono T, Okano K, Yoshikawa Y, Aotsuka S, Sasaki N, Hattori A, Okumura K, Nagai K, Sugano S, Isogai T (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Research. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.
  • Shibatani T, David LL, McCormack AL, Frueh K, Skach WR (April 2005). "Proteomic analysis of mammalian oligosaccharyltransferase reveals multiple subcomplexes that contain Sec61, TRAP, and two potential new subunits". Biochemistry. 44 (16): 5982–92. doi:10.1021/bi047328f. PMID 15835887.