StAR-related lipid transfer domain protein 7 (STARD7) or gestational trophoblastic tumor gene-1 (GTT1) is a lipid transporter that specifically binds and transports phosphatidylcholine between membranes.[5]

STARD7
Identifiers
AliasesSTARD7, GTT1, StAR related lipid transfer domain containing 7, FAME2
External IDsOMIM: 616712; MGI: 2139090; HomoloGene: 32463; GeneCards: STARD7; OMA:STARD7 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_020151
NM_139267
NM_001385622

NM_139308
NM_001362684

RefSeq (protein)

NP_064536

NP_647469
NP_001349613

Location (UCSC)Chr 2: 96.18 – 96.21 MbChr 2: 127.11 – 127.14 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function and tissue distribution

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StarD7 is found in the cytosol and associated with the mitochondrion.[5] When overproduced in the cell, mitochondrial levels of phosphatidylcholine rise.[5] High levels of the protein are found in tumor cells compared to normal cells, suggesting a role in cell proliferation.[6]

Structure

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There are two forms of StarD7: StarD7-I and StarD7-II. The former is 295 amino acids long. StarD7-I possesses an additional 75 amino acids at its amino-terminus, which form a signaling sequence that targets it to the outer membrane of the mitochondrion.[5]

StarD7 contains a StAR-related transfer domain (START), from which it derives its name. Moreover, the protein is a member of the predominantly phosphatidylcholine transporter subfamily of START proteins, the StarD2 subfamily. It shares 25% sequence identity with StarD2.[5]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000084090Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000027367Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b c d e Horibata Y, Sugimoto H (March 2010). "StarD7 mediates the intracellular trafficking of phosphatidylcholine to mitochondria". The Journal of Biological Chemistry. 285 (10): 7358–65. doi:10.1074/jbc.M109.056960. PMC 2844184. PMID 20042613.
  6. ^ Durand S, Angeletti S, Genti-Raimondi S (January 2004). "GTT1/StarD7, a novel phosphatidylcholine transfer protein-like highly expressed in gestational trophoblastic tumour: cloning and characterization". Placenta. 25 (1): 37–44. doi:10.1016/S0143-4004(03)00214-5. PMID 15013637.