Protein SSX5 is a protein that in humans is encoded by the SSX5 gene.[3]

SSX5
Identifiers
AliasesSSX5, SSX family member 5
External IDsOMIM: 300327; HomoloGene: 137346; GeneCards: SSX5; OMA:SSX5 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_021015
NM_175723

n/a

RefSeq (protein)

NP_066295
NP_783729

n/a

Location (UCSC)Chr X: 48.19 – 48.2 Mbn/a
PubMed search[2]n/a
Wikidata
View/Edit Human

Function

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The product of this gene belongs to the family of highly homologous synovial sarcoma, X (SSX) breakpoint proteins. These proteins may function as transcriptional repressors. They are also capable of eliciting spontaneously humoral and cellular immune responses in cancer patients, and are potentially useful targets in cancer vaccine-based immunotherapy. SSX1, SSX2 and SSX4 genes have been involved in the t(X;18) chromosomal translocation characteristically found in all synovial sarcomas. This gene appears not to be involved in this type of translocation. Two transcript variants encoding distinct isoforms have been identified for this gene.[3]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000165583Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ a b "Entrez Gene: SSX5 synovial sarcoma, X breakpoint 5".

Further reading

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