SSX5

Protein SSX5 is a protein that in humans is encoded by the SSX5 gene.

SSX5
Identifiers
Aliases	SSX5, SSX family member 5
External IDs	OMIM: 300327; HomoloGene: 137346; GeneCards: SSX5; OMA:SSX5 - orthologs
Gene location (Human) Chr. X chromosome (human) Band Xp11.23 Start 48,186,220 bp End 48,196,795 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gonad testicle right uterine tube pharynx human musculoskeletal system tonsil placenta renal cortex muscular system muscle n/a More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding transcription corepressor activity nucleic acid binding Cellular component intracellular anatomical structure nucleus Biological process negative regulation of nucleic acid-templated transcription regulation of transcription, DNA-templated transcription, DNA-templated Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6758 n/a Ensembl ENSG00000165583 n/a UniProt O60225 n/a RefSeq (mRNA) NM_021015 NM_175723 n/a RefSeq (protein) NP_066295 NP_783729 n/a Location (UCSC) Chr X: 48.19 – 48.2 Mb n/a PubMed search n/a
Wikidata
View/Edit Human

Function

The product of this gene belongs to the family of highly homologous synovial sarcoma, X (SSX) breakpoint proteins. These proteins may function as transcriptional repressors. They are also capable of eliciting spontaneously humoral and cellular immune responses in cancer patients, and are potentially useful targets in cancer vaccine-based immunotherapy. SSX1, SSX2 and SSX4 genes have been involved in the t(X;18) chromosomal translocation characteristically found in all synovial sarcomas. This gene appears not to be involved in this type of translocation. Two transcript variants encoding distinct isoforms have been identified for this gene.

Further reading

• dos Santos NR, de Bruijn DR, van Kessel AG (January 2001). "Molecular mechanisms underlying human synovial sarcoma development". Genes, Chromosomes & Cancer. 30 (1): 1–14. doi:10.1002/1098-2264(2000)9999:9999<::AID-GCC1056>3.0.CO;2-G. PMID 11107170. S2CID 24403558.
• Gure AO, Türeci O, Sahin U, Tsang S, Scanlan MJ, Jäger E, Knuth A, Pfreundschuh M, Old LJ, Chen YT (September 1997). "SSX: a multigene family with several members transcribed in normal testis and human cancer". International Journal of Cancer. 72 (6): 965–71. doi:10.1002/(SICI)1097-0215(19970917)72:6<965::AID-IJC8>3.0.CO;2-N. PMID 9378559. S2CID 21203036.
• Chen CH, Chen GJ, Lee HS, Huang GT, Yang PM, Tsai LJ, Chen DS, Sheu JC (March 2001). "Expressions of cancer-testis antigens in human hepatocellular carcinomas". Cancer Letters. 164 (2): 189–95. doi:10.1016/S0304-3835(01)00379-2. PMID 11179834.
• de Bruijn DR, dos Santos NR, Kater-Baats E, Thijssen J, van den Berk L, Stap J, Balemans M, Schepens M, Merkx G, van Kessel AG (July 2002). "The cancer-related protein SSX2 interacts with the human homologue of a Ras-like GTPase interactor, RAB3IP, and a novel nuclear protein, SSX2IP". Genes, Chromosomes & Cancer. 34 (3): 285–98. doi:10.1002/gcc.10073. PMID 12007189. S2CID 11734893.
• Güre AO, Wei IJ, Old LJ, Chen YT (October 2002). "The SSX gene family: characterization of 9 complete genes". International Journal of Cancer. 101 (5): 448–53. doi:10.1002/ijc.10634. PMID 12216073. S2CID 21174312.
• Wu LQ, Lu Y, Wang XF, Lv ZH, Zhang B, Yang JY (July 2006). "Expression of cancer-testis antigen (CTA) in tumor tissues and peripheral blood of Chinese patients with hepatocellular carcinoma". Life Sciences. 79 (8): 744–8. doi:10.1016/j.lfs.2006.02.024. PMID 16546222.