Spinster homolog 2 (Drosophila) is a protein that in humans is encoded by the SPNS2 gene.[5]

SPNS2
Identifiers
AliasesSPNS2, sphingolipid transporter 2, SLC62A2, DFNB115, SLC63A2
External IDsOMIM: 612584; MGI: 2384936; HomoloGene: 71040; GeneCards: SPNS2; OMA:SPNS2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001124758

NM_001276383
NM_153060

RefSeq (protein)

NP_001118230

NP_001263312
NP_694700

Location (UCSC)Chr 17: 4.5 – 4.54 MbChr 11: 72.34 – 72.38 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Model organisms

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The orthologous protein in zebrafish has been shown to transport sphingosine-1-phosphate (S1P) out of cells during vascular development, and human SPNS2 can transport S1P analogues, including the immunomodulating drug FTY720-P.[6][7]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000183018Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000040447Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Spinster homolog 2 (Drosophila)". Retrieved 2011-12-04.
  6. ^ Kawahara A, Nishi T, Hisano Y, Fukui H, Yamaguchi A, Mochizuki N (January 2009). "The sphingolipid transporter spns2 functions in migration of zebrafish myocardial precursors". Science. 323 (5913): 524–7. Bibcode:2009Sci...323..524K. doi:10.1126/science.1167449. PMID 19074308. S2CID 44826764.
  7. ^ Hisano Y, Kobayashi N, Kawahara A, Yamaguchi A, Nishi T (January 2011). "The sphingosine 1-phosphate transporter, SPNS2, functions as a transporter of the phosphorylated form of the immunomodulating agent FTY720". The Journal of Biological Chemistry. 286 (3): 1758–66. doi:10.1074/jbc.M110.171116. PMC 3023470. PMID 21084291.