Sphingosine kinase 2 is a protein that in humans is encoded by the SPHK2 gene.[5]

SPHK2
Identifiers
AliasesSPHK2, SK 2, SK-2, SPK 2, SPK-2, sphingosine kinase 2
External IDsOMIM: 607092; MGI: 1861380; HomoloGene: 32456; GeneCards: SPHK2; OMA:SPHK2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001204158
NM_001204159
NM_001204160
NM_001243876
NM_020126

NM_001172561
NM_020011
NM_203280

RefSeq (protein)

NP_001191087
NP_001191088
NP_001191089
NP_001230805
NP_064511

NP_001166032
NP_064395
NP_975009

Location (UCSC)Chr 19: 48.62 – 48.63 MbChr 7: 45.36 – 45.37 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

This gene encodes one of two sphingosine kinase isozymes that catalyze the phosphorylation of sphingosine into sphingosine 1-phosphate. Sphingosine 1-phosphate mediates many cellular processes including migration, proliferation and apoptosis, and also plays a role in several types of cancer by promoting angiogenesis and tumorigenesis. The encoded protein may play a role in breast cancer proliferation and chemoresistance. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.[5][6]

The researchers also found that the expression of sphingosine kinase 2 (SphK2) and the secretion of sphingosine-1-phosphate (S1P) were significantly upregulated in the lungs of CS-exposed mice with COPD-like symptoms.[7]

Inhibitors

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References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000063176Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000057342Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: Sphingosine kinase 2". Retrieved 2011-12-22.
  6. ^ [provided by RefSeq, Aug 2011].
  7. ^ Chen Y, Zhang Y, Rao C, Huang J, Qing Q (2023-03-16). "Deletion of sphingosine kinase 2 attenuates cigarette smoke-mediated chronic obstructive pulmonary disease-like symptoms by reducing lung inflammation". Biomolecules and Biomedicine. 23 (2): 259–270. doi:10.17305/bjbms.2022.8034. ISSN 2831-090X. PMC 10113950. PMID 36226596.

Further reading

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