SAM pointed domain-containing Ets transcription factor is a protein that in humans is encoded by the SPDEF gene.[5][6][7]

SPDEF
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesSPDEF, PDEF, bA375E1.3, SAM pointed domain containing ETS transcription factor
External IDsOMIM: 608144; MGI: 1353422; HomoloGene: 8231; GeneCards: SPDEF; OMA:SPDEF - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001252294
NM_012391

NM_013891
NM_001357728

RefSeq (protein)

NP_001239223
NP_036523

NP_038919
NP_001344657

Location (UCSC)Chr 6: 34.54 – 34.56 MbChr 17: 27.93 – 27.95 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

PDEF is an ETS transcription factor expressed in prostate epithelial cells. It acts as an androgen-independent transactivator of PSA (MIM 176820) expression.[supplied by OMIM][7]

Interactions

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SPDEF has been shown to interact with NKX3-1.[8]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000124664Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000024215Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Oettgen P, Finger E, Sun Z, Akbarali Y, Thamrongsak U, Boltax J, et al. (January 2000). "PDEF, a novel prostate epithelium-specific ets transcription factor, interacts with the androgen receptor and activates prostate-specific antigen gene expression". The Journal of Biological Chemistry. 275 (2): 1216–1225. doi:10.1074/jbc.275.2.1216. PMID 10625666.
  6. ^ Johannessen JV, Finseth I (January 1983). "Electron micrographs in five minutes". Ultrastructural Pathology. 4 (1): 97–100. doi:10.3109/01913128309140576. PMID 6857767.
  7. ^ a b "Entrez Gene: SPDEF SAM pointed domain containing ets transcription factor".
  8. ^ Chen H, Nandi AK, Li X, Bieberich CJ (January 2002). "NKX-3.1 interacts with prostate-derived Ets factor and regulates the activity of the PSA promoter". Cancer Research. 62 (2): 338–340. PMID 11809674.

Further reading

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