SNX27

Sorting nexin family member 27, also known as SNX27, is a human gene.

SNX27
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4HAS
Identifiers
Aliases	SNX27, MRT1, MY014, sorting nexin family member 27, sorting nexin 27
External IDs	OMIM: 611541; MGI: 1923992; HomoloGene: 12797; GeneCards: SNX27; OMA:SNX27 - orthologs
Gene location (Human) Chr. Chromosome 1 (human) Band 1q21.3 Start 151,612,006 bp End 151,699,091 bp
Gene location (Mouse) Chr. Chromosome 3 (mouse) Band 3|3 F2.1 Start 94,404,851 bp End 94,490,023 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in internal globus pallidus optic nerve external globus pallidus superior vestibular nucleus inferior ganglion of vagus nerve lateral nuclear group of thalamus ventral tegmental area subthalamic nucleus monocyte pars compacta Top expressed in otic vesicle tail of embryo otolith organ utricle Rostral migratory stream ventromedial nucleus lateral septal nucleus dentate gyrus of hippocampal formation granule cell hand spermatocyte More reference expression data BioGPS More reference expression data
Gene ontology Molecular function phosphatidylinositol-3-phosphate binding protein binding phosphatidylinositol binding lipid binding Cellular component early endosome membrane membrane nucleoplasm retromer complex early endosome immunological synapse WASH complex cytoplasm endosome cytosol Biological process establishment of natural killer cell polarity endosome to lysosome transport endosomal transport protein transport intracellular protein transport signal transduction Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 81609 76742 Ensembl ENSG00000143376 ENSMUSG00000028136 UniProt Q96L92 Q3UHD6 RefSeq (mRNA) NM_030918 NM_001330723 NM_001082484 NM_029721 RefSeq (protein) NP_001317652 NP_112180 NP_001075953 NP_083997 Location (UCSC) Chr 1: 151.61 – 151.7 Mb Chr 3: 94.4 – 94.49 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

This gene encodes a member of the sorting nexin family, a diverse group of cytoplasmic and membrane-associated proteins involved in endocytosis of plasma membrane receptors and protein trafficking through these compartments. All members of this protein family contain a phosphoinositide binding domain (PX domain). A highly similar protein in mice is responsible for the specific recruitment of an isoform of the serotonin 5-hydroxytryptamine 4 receptor into early endosomes, suggesting the analogous role for the human protein.

Further reading

• Worby CA, Dixon JE (December 2002). "Sorting out the cellular functions of sorting nexins". Nature Reviews. Molecular Cell Biology. 3 (12): 919–31. doi:10.1038/nrm974. PMID 12461558. S2CID 36361630.
• Bonaldo MF, Lennon G, Soares MB (September 1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Research. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
• Seki N, Ohira M, Nagase T, Ishikawa K, Miyajima N, Nakajima D, Nomura N, Ohara O (October 1997). "Characterization of cDNA clones in size-fractionated cDNA libraries from human brain". DNA Research. 4 (5): 345–9. doi:10.1093/dnares/4.5.345. PMID 9455484.
• Teasdale RD, Loci D, Houghton F, Karlsson L, Gleeson PA (August 2001). "A large family of endosome-localized proteins related to sorting nexin 1". The Biochemical Journal. 358 (Pt 1): 7–16. doi:10.1042/0264-6021:3580007. PMC 1222026. PMID 11485546.
• Williams R, Schlüter T, Roberts MS, Knauth P, Bohnensack R, Cutler DF (July 2004). "Sorting nexin 17 accelerates internalization yet retards degradation of P-selectin". Molecular Biology of the Cell. 15 (7): 3095–105. doi:10.1091/mbc.E04-02-0143. PMC 452567. PMID 15121882.
• Joubert L, Hanson B, Barthet G, Sebben M, Claeysen S, Hong W, Marin P, Dumuis A, Bockaert J (October 2004). "New sorting nexin (SNX27) and NHERF specifically interact with the 5-HT4a receptor splice variant: roles in receptor targeting". Journal of Cell Science. 117 (Pt 22): 5367–79. doi:10.1242/jcs.01379. PMID 15466885.
• Rincón E, Santos T, Avila-Flores A, Albar JP, Lalioti V, Lei C, Hong W, Mérida I (June 2007). "Proteomics identification of sorting nexin 27 as a diacylglycerol kinase zeta-associated protein: new diacylglycerol kinase roles in endocytic recycling". Molecular & Cellular Proteomics. 6 (6): 1073–87. doi:10.1074/mcp.M700047-MCP200. PMID 17351151.
• MacNeil AJ, Mansour M, Pohajdak B (August 2007). "Sorting nexin 27 interacts with the Cytohesin associated scaffolding protein (CASP) in lymphocytes". Biochemical and Biophysical Research Communications. 359 (4): 848–53. doi:10.1016/j.bbrc.2007.05.162. PMID 17577583.