Open main menu

Sperm mitochondrial-associated cysteine-rich protein is a protein that in humans is encoded by the SMCP gene.[3][4]

SMCP
Identifiers
AliasesSMCP, HSMCSGEN1, MCS, MCSP, sperm mitochondria associated cysteine rich protein
External IDsOMIM: 601148 HomoloGene: 136205 GeneCards: SMCP
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for SMCP
Genomic location for SMCP
Band1q21.3Start152,878,322 bp[1]
End152,885,047 bp[1]
RNA expression pattern
PBB GE SMCP 206406 at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_030663

n/a

RefSeq (protein)

NP_109588

n/a

Location (UCSC)Chr 1: 152.88 – 152.89 Mbn/a
PubMed search[2]n/a
Wikidata
View/Edit Human

FunctionEdit

Sperm mitochondria differ in morphology and subcellular localization from those of somatic cells. They are elongated, flattened, and arranged circumferentially to form a helical coiled sheath in the midpiece of the sperm flagellum. The protein encoded by this gene localizes to the capsule associated with the mitochondrial outer membranes and is thought to function in the organization and stabilization of the helical structure of the sperm's mitochondrial sheath.[4]

ReferencesEdit

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000163206 - Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ Aho H, Schwemmer M, Tessman D, Murphy D, Mattei G, Engel W, Adham IM (Mar 1996). "Isolation, expression, and chromosomal localization of the human mitochondrial capsule selenoprotein gene (MCSP)". Genomics. 32 (2): 184–90. doi:10.1006/geno.1996.0104. PMID 8833144.
  4. ^ a b "Entrez Gene: SMCP sperm mitochondria-associated cysteine-rich protein".

Further readingEdit