SLAM family member 6 is a protein that in humans is encoded by the SLAMF6 gene.[5][6]

SLAMF6
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesSLAMF6, CD352, KALI, KALIb, Ly108, NTB-A, NTBA, SF2000, SLAM family member 6
External IDsOMIM: 606446; MGI: 1353620; HomoloGene: 49945; GeneCards: SLAMF6; OMA:SLAMF6 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_052931
NM_001184714
NM_001184715
NM_001184716

NM_030710
NM_001347186
NM_001347187

RefSeq (protein)

NP_001171643
NP_001171644
NP_001171645
NP_443163

NP_001334115
NP_001334116
NP_109635

Location (UCSC)Chr 1: 160.49 – 160.52 MbChr 1: 171.75 – 171.78 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

The protein encoded by this gene is a type I transmembrane protein, belonging to the CD2 subfamily of the immunoglobulin superfamily. This encoded protein is expressed on natural killer (NK), T, and B lymphocytes. It undergoes tyrosine phosphorylation and associates with the Src homology 2 domain-containing protein (SH2D1A) as well as with SH2 domain-containing phosphatases (SHPs). It may function as a coreceptor in the process of NK cell activation. It can also mediate inhibitory signals in NK cells from X-linked lymphoproliferative patients.[6]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000162739Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000015314Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Bottino C, Falco M, Parolini S, Marcenaro E, Augugliaro R, Sivori S, Landi E, Biassoni R, Notarangelo LD, Moretta L, Moretta A (Aug 2001). "NTB-A [correction of GNTB-A], a novel SH2D1A-associated surface molecule contributing to the inability of natural killer cells to kill Epstein-Barr virus-infected B cells in X-linked lymphoproliferative disease". J Exp Med. 194 (3): 235–46. doi:10.1084/jem.194.3.235. PMC 2193462. PMID 11489943.
  6. ^ a b "Entrez Gene: SLAMF6 SLAM family member 6".

Further reading

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