Ski-like protein is a protein that in humans is encoded by the SKIL gene.[5][6]

SKIL
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesSKIL, SNO, SnoA, SnoI, SnoN, SKI-like proto-oncogene, SKI like proto-oncogene
External IDsOMIM: 165340 MGI: 106203 HomoloGene: 3948 GeneCards: SKIL
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001145097
NM_001145098
NM_001248008
NM_005414

NM_001039090
NM_001271772
NM_011386

RefSeq (protein)

NP_001138569
NP_001138570
NP_001234937
NP_005405

NP_001034179
NP_001258701
NP_035516

Location (UCSC)Chr 3: 170.36 – 170.4 MbChr 3: 31.1 – 31.12 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

InteractionsEdit

SKIL interacts with SKI protein,[7] Mothers against decapentaplegic homolog 3[8][9] and Mothers against decapentaplegic homolog 2.[8][9]

Protein FamilyEdit

SKIL belongs to the Ski/Sno/Dac family, shared by SKI protein, Dachshund, and SKIDA1.[10] Members of the Ski/Sno/Dac family share a domain that is roughly 100 amino acids long.

ReferencesEdit

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000136603 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000027660 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Nomura N; Sasamoto S; Ishii S; Date T; Matsui M; Ishizaki R (September 1989). "Isolation of human cDNA clones of ski and the ski-related gene, sno". Nucleic Acids Res. 17 (14): 5489–500. doi:10.1093/nar/17.14.5489. PMC 318172. PMID 2762147.
  6. ^ "Entrez Gene: SKIL SKI-like oncogene".
  7. ^ Cohen, S B; Zheng G; Heyman H C; Stavnezer E (February 1999). "Heterodimers of the SnoN and Ski oncoproteins form preferentially over homodimers and are more potent transforming agents". Nucleic Acids Res. ENGLAND. 27 (4): 1006–14. doi:10.1093/nar/27.4.1006. ISSN 0305-1048. PMC 148280. PMID 9927733.
  8. ^ a b Stroschein, S L; Bonni S; Wrana J L; Luo K (November 2001). "Smad3 recruits the anaphase-promoting complex for ubiquitination and degradation of SnoN". Genes Dev. United States. 15 (21): 2822–36. doi:10.1101/gad.912901 (inactive 2021-01-14). ISSN 0890-9369. PMC 312804. PMID 11691834.CS1 maint: DOI inactive as of January 2021 (link)
  9. ^ a b Stroschein, S L; Wang W; Zhou S; Zhou Q; Luo K (October 1999). "Negative feedback regulation of TGF-beta signaling by the SnoN oncoprotein". Science. UNITED STATES. 286 (5440): 771–4. doi:10.1126/science.286.5440.771. ISSN 0036-8075. PMID 10531062.
  10. ^ "Conserved Protein Domain Family Ski_Sno". NCBI. Retrieved 5 May 2019.

Further readingEdit