Ski-like protein is a protein that in humans is encoded by the SKIL gene.[5][6]

SKIL
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesSKIL, SNO, SnoA, SnoI, SnoN, SKI-like proto-oncogene, SKI like proto-oncogene
External IDsOMIM: 165340; MGI: 106203; HomoloGene: 3948; GeneCards: SKIL; OMA:SKIL - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001145097
NM_001145098
NM_001248008
NM_005414

RefSeq (protein)

NP_001138569
NP_001138570
NP_001234937
NP_005405

Location (UCSC)Chr 3: 170.36 – 170.4 MbChr 3: 31.15 – 31.18 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Interactions

edit

SKIL interacts with SKI protein,[7] Mothers against decapentaplegic homolog 3[8][9] and Mothers against decapentaplegic homolog 2.[8][9]

Protein Family

edit

SKIL belongs to the Ski/Sno/Dac family, shared by SKI protein, Dachshund, and SKIDA1.[10] Members of the Ski/Sno/Dac family share a domain that is roughly 100 amino acids long.

References

edit
  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000136603Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000027660Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Nomura N; Sasamoto S; Ishii S; Date T; Matsui M; Ishizaki R (September 1989). "Isolation of human cDNA clones of ski and the ski-related gene, sno". Nucleic Acids Res. 17 (14): 5489–500. doi:10.1093/nar/17.14.5489. PMC 318172. PMID 2762147.
  6. ^ "Entrez Gene: SKIL SKI-like oncogene".
  7. ^ Cohen, S B; Zheng G; Heyman H C; Stavnezer E (February 1999). "Heterodimers of the SnoN and Ski oncoproteins form preferentially over homodimers and are more potent transforming agents". Nucleic Acids Res. 27 (4). ENGLAND: 1006–14. doi:10.1093/nar/27.4.1006. ISSN 0305-1048. PMC 148280. PMID 9927733.
  8. ^ a b Stroschein, S L; Bonni S; Wrana J L; Luo K (November 2001). "Smad3 recruits the anaphase-promoting complex for ubiquitination and degradation of SnoN". Genes Dev. 15 (21). United States: 2822–36. doi:10.1101/gad.912901. ISSN 0890-9369. PMC 312804. PMID 11691834.
  9. ^ a b Stroschein, S L; Wang W; Zhou S; Zhou Q; Luo K (October 1999). "Negative feedback regulation of TGF-beta signaling by the SnoN oncoprotein". Science. 286 (5440). UNITED STATES: 771–4. doi:10.1126/science.286.5440.771. ISSN 0036-8075. PMID 10531062.
  10. ^ "Conserved Protein Domain Family Ski_Sno". NCBI. Retrieved 5 May 2019.

Further reading

edit