E3 ubiquitin-protein ligase SHPRH is an enzyme that in humans is encoded by the SHPRH gene.[5][6]

SHPRH
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesSHPRH, bA545I5.2, SNF2 histone linker PHD RING helicase, RAD5
External IDsOMIM: 608048; MGI: 1917581; HomoloGene: 6489; GeneCards: SHPRH; OMA:SHPRH - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001042683
NM_173082
NM_001370327
NM_001370328

NM_001077707
NM_001284354
NM_172937

RefSeq (protein)

NP_001036148
NP_775105
NP_001357256
NP_001357257

NP_001071175
NP_001271283
NP_766525

Location (UCSC)Chr 6: 145.86 – 145.96 MbChr 10: 11.03 – 11.09 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

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SHPRH is a ubiquitously expressed protein that contains motifs characteristics of several DNA repair proteins, transcription factors, and helicases.[supplied by OMIM][6] SHPRH is a nucleosome-stimulated ATPase and a nucleosome-E3 ubiquitin ligase.[7]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000146414Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000090112Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Sood R, Makalowska I, Galdzicki M, Hu P, Eddings E, Robbins CM, Moses T, Namkoong J, Chen S, Trent JM (August 2003). "Cloning and characterization of a novel gene, SHPRH, encoding a conserved putative protein with SNF2/helicase and PHD-finger domains from the 6q24 region". Genomics. 82 (2): 153–61. doi:10.1016/S0888-7543(03)00121-6. PMID 12837266.
  6. ^ a b "Entrez Gene: SHPRH SNF2 histone linker PHD RING helicase".
  7. ^ Brühl, J; Trautwein, J; Schäfer, A; Linne, U; Bouazoune, K (21 August 2019). "The DNA repair protein SHPRH is a nucleosome-stimulated ATPase and a nucleosome-E3 ubiquitin ligase". Epigenetics & Chromatin. 12 (1): 52. doi:10.1186/s13072-019-0294-5. PMC 6702750. PMID 31434570.

Further reading

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