Putative E3 ubiquitin-protein ligase SH3RF1 is an enzyme that in humans is encoded by the SH3RF1 gene.[5][6]

SH3RF1
Identifiers
AliasesSH3RF1, POSH, RNF142, SH3MD2, SH3 domain containing ring finger 1
External IDsMGI: 1913066; HomoloGene: 10988; GeneCards: SH3RF1; OMA:SH3RF1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_020870

NM_021506
NM_198678

RefSeq (protein)

NP_065921

NP_067481

Location (UCSC)Chr 4: 169.09 – 169.27 MbChr 8: 61.68 – 61.85 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

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This gene encodes a protein containing an N-terminus RING-finger, four SH3 domains, and a region implicated in binding of the Rho GTPase Rac. Via the RING-finger, the encoded protein has been shown to function as a ubiquitin-protein ligase involved in protein sorting at the trans-Golgi network. The encoded protein may also act as a scaffold for the c-Jun N-terminal kinase signaling pathway, facilitating the formation of a functional signaling module.[6]

Interactions

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SH3RF1 has been shown to interact with AKT2[7] and MAP3K11.[7]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000154447Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000031642Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Tapon N, Nagata K, Lamarche N, Hall A (Apr 1998). "A new rac target POSH is an SH3-containing scaffold protein involved in the JNK and NF-kappaB signalling pathways". EMBO J. 17 (5): 1395–404. doi:10.1093/emboj/17.5.1395. PMC 1170487. PMID 9482736.
  6. ^ a b "Entrez Gene: SH3RF1 SH3 domain containing ring finger 1".
  7. ^ a b Figueroa C, Tarras S, Taylor J, Vojtek AB (Nov 2003). "Akt2 negatively regulates assembly of the POSH-MLK-JNK signaling complex". J. Biol. Chem. 278 (48): 47922–7. doi:10.1074/jbc.M307357200. PMID 14504284.

Further reading

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