SFRS4

Splicing factor, arginine/serine-rich 4 is a protein that in humans is encoded by the SFRS4 gene.

SRSF4
Identifiers
Aliases	SRSF4, SFRS4, SRP75, serine/arginine-rich splicing factor 4, serine and arginine rich splicing factor 4
External IDs	OMIM: 601940 MGI: 1890577 HomoloGene: 25624 GeneCards: SRSF4
Gene location (Human) Chr. Chromosome 1 (human) Band 1p35.3 Start 29,147,743 bp End 29,181,900 bp
Gene location (Mouse) Chr. Chromosome 4 (mouse) Band 4|4 D2.3 Start 131,873,617 bp End 131,901,706 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sural nerve middle frontal gyrus canal of the cervix gastric mucosa right lung left lobe of thyroid gland left uterine tube ganglionic eminence right lobe of thyroid gland upper lobe of left lung Top expressed in ascending aorta aortic valve primitive streak ganglionic eminence somite maxillary prominence retinal pigment epithelium ureter hair follicle abdominal wall More reference expression data BioGPS More reference expression data
Gene ontology Molecular function sequence-specific mRNA binding nucleic acid binding protein binding RNA binding nucleotide binding Cellular component nucleus nucleoplasm nuclear speck Biological process RNA splicing, via transesterification reactions mRNA splicing, via spliceosome termination of RNA polymerase II transcription mRNA processing negative regulation of mRNA splicing, via spliceosome mRNA 3'-end processing mRNA export from nucleus RNA splicing RNA export from nucleus response to insulin regulation of alternative mRNA splicing, via spliceosome mRNA cis splicing, via spliceosome Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6429 57317 Ensembl ENSG00000116350 ENSMUSG00000028911 UniProt Q08170 Q8VE97 RefSeq (mRNA) NM_005626 NM_020587 RefSeq (protein) NP_005617 n/a Location (UCSC) Chr 1: 29.15 – 29.18 Mb Chr 4: 131.87 – 131.9 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Interactions

SFRS4 has been shown to interact with Pinin.

Further reading

• Zahler AM; Lane WS; Stolk JA; Roth MB (1992). "SR proteins: a conserved family of pre-mRNA splicing factors". Genes Dev. 6 (5): 837–47. doi:10.1101/gad.6.5.837. PMID 1577277.
• Ramchatesingh J, Zahler AM, Neugebauer KM, et al. (1995). "A subset of SR proteins activates splicing of the cardiac troponin T alternative exon by direct interactions with an exonic enhancer". Mol. Cell. Biol. 15 (9): 4898–907. doi:10.1128/MCB.15.9.4898. PMC 230736. PMID 7651409.
• Maruyama K; Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Gui JF; Lane WS; Fu XD (1994). "A serine kinase regulates intracellular localization of splicing factors in the cell cycle". Nature. 369 (6482): 678–82. Bibcode:1994Natur.369..678G. doi:10.1038/369678a0. PMID 8208298. S2CID 4275539. Archived from the original on 2020-12-03. Retrieved 2019-12-12.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Zhang WJ; Wu JY (1998). "Sip1, a Novel RS Domain-Containing Protein Essential for Pre-mRNA Splicing". Mol. Cell. Biol. 18 (2): 676–84. doi:10.1128/MCB.18.2.676. PMC 108778. PMID 9447963.
• Blencowe BJ; Issner R; Nickerson JA; Sharp PA (1998). "A coactivator of pre-mRNA splicing". Genes Dev. 12 (7): 996–1009. doi:10.1101/gad.12.7.996. PMC 316672. PMID 9531537.
• Papoutsopoulou S, Nikolakaki E, Chalepakis G, et al. (1999). "SR protein-specific kinase 1 is highly expressed in testis and phosphorylates protamine 1". Nucleic Acids Res. 27 (14): 2972–80. doi:10.1093/nar/27.14.2972. PMC 148514. PMID 10390541.
• Monsalve M, Wu Z, Adelmant G, et al. (2000). "Direct coupling of transcription and mRNA processing through the thermogenic coactivator PGC-1". Mol. Cell. 6 (2): 307–16. doi:10.1016/S1097-2765(00)00031-9. PMID 10983978.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Meissner M, Lopato S, Gotzmann J, et al. (2003). "Proto-oncoprotein TLS/FUS is associated to the nuclear matrix and complexed with splicing factors PTB, SRm160, and SR proteins". Exp. Cell Res. 283 (2): 184–95. doi:10.1016/S0014-4827(02)00046-0. PMID 12581738.
• Li J, Hawkins IC, Harvey CD, et al. (2003). "Regulation of Alternative Splicing by SRrp86 and Its Interacting Proteins". Mol. Cell. Biol. 23 (21): 7437–47. doi:10.1128/MCB.23.21.7437-7447.2003. PMC 207616. PMID 14559993.
• Zimowska G, Shi J, Munguba G, et al. (2003). "Pinin/DRS/memA interacts with SRp75, SRm300 and SRrp130 in corneal epithelial cells". Invest. Ophthalmol. Vis. Sci. 44 (11): 4715–23. doi:10.1167/iovs.03-0240. PMID 14578391.
• de Graaf K, Hekerman P, Spelten O, et al. (2004). "Characterization of cyclin L2, a novel cyclin with an arginine/serine-rich domain: phosphorylation by DYRK1A and colocalization with splicing factors". J. Biol. Chem. 279 (6): 4612–24. doi:10.1074/jbc.M310794200. PMID 14623875.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Rush J, Moritz A, Lee KA, et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nat. Biotechnol. 23 (1): 94–101. doi:10.1038/nbt1046. PMID 15592455. S2CID 7200157.
• Barrios-Rodiles M, Brown KR, Ozdamar B, et al. (2005). "High-throughput mapping of a dynamic signaling network in mammalian cells". Science. 307 (5715): 1621–5. Bibcode:2005Sci...307.1621B. doi:10.1126/science.1105776. PMID 15761153. S2CID 39457788.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.