SEPT10

Septin 10 is a protein that in humans is encoded by the SEPT10 gene.

SEPTIN10
Identifiers
Aliases	SEPTIN10, septin 10, SEPT10
External IDs	OMIM: 611737; MGI: 1918110; HomoloGene: 27035; GeneCards: SEPTIN10; OMA:SEPTIN10 - orthologs
Gene location (Human) Chr. Chromosome 2 (human) Band 2q13 Start 109,542,799 bp End 109,614,143 bp
Gene location (Mouse) Chr. Chromosome 10 (mouse) Band 10|10 B4 Start 59,141,627 bp End 59,221,847 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in oral cavity germinal epithelium human penis hair follicle amniotic fluid parietal pleura Achilles tendon synovial joint gums lower lobe of lung Top expressed in spermatocyte spermatid atrioventricular valve endocardial cushion seminiferous tubule corneal stroma interventricular septum aortic valve ascending aorta sciatic nerve More reference expression data BioGPS n/a
Gene ontology Molecular function nucleotide binding GTP binding protein binding GTPase activity molecular adaptor activity Cellular component cytoplasm cytoskeleton septin ring microtubule cytoskeleton septin complex septin filament array Biological process cell cycle cell division mitotic cytokinesis septin ring assembly cilium assembly cytoskeleton-dependent cytokinesis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 151011 103080 Ensembl ENSG00000186522 ENSMUSG00000019917 UniProt Q9P0V9 Q8C650 RefSeq (mRNA) NM_144710 NM_178584 NM_001321496 NM_001321498 NM_001321499 NM_001321500 NM_001321501 NM_001321502 NM_001321503 NM_001321504 NM_001321505 NM_001321506 NM_001321507 NM_001321508 NM_001321509 NM_001321510 NM_001321511 NM_001321512 NM_001321513 NM_001321514 NM_001321515 NM_001024910 NM_001024911 RefSeq (protein) NP_001308425 NP_001308427 NP_001308428 NP_001308429 NP_001308430 NP_001308431 NP_001308432 NP_001308433 NP_001308434 NP_001308435 NP_001308436 NP_001308437 NP_001308438 NP_001308439 NP_001308440 NP_001308441 NP_001308442 NP_001308443 NP_001308444 NP_653311 NP_848699 NP_001308427.1 NP_001020081 NP_001020082 NP_001365992 NP_001365993 NP_001365994 NP_001365995 Location (UCSC) Chr 2: 109.54 – 109.61 Mb Chr 10: 59.14 – 59.22 Mb PubMed search
Wikidata
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Function

This gene encodes a member of the septin family of cytoskeletal proteins with GTPase activity. This protein localizes to the cytoplasm and nucleus and displays GTP-binding and GTPase activity. Alternative splicing results in multiple transcript variants.

Further reading

• Sui L, Zhang W, Liu Q, Chen T, Li N, Wan T, Yu M, Cao X (May 2003). "Cloning and functional characterization of human septin 10, a novel member of septin family cloned from dendritic cells". Biochemical and Biophysical Research Communications. 304 (2): 393–8. doi:10.1016/s0006-291x(03)00601-6. PMID 12711328.
• Benedetti D, Bomben R, Dal-Bo M, Marconi D, Zucchetto A, Degan M, Forconi F, Del-Poeta G, Gaidano G, Gattei V (January 2008). "Are surrogates of IGHV gene mutational status useful in B-cell chronic lymphocytic leukemia? The example of Septin-10". Leukemia. 22 (1): 224–6. doi:10.1038/sj.leu.2404867. PMID 17657217.
• Xu M, Takanashi M, Oikawa K, Nishi H, Isaka K, Yoshimoto T, Ohyashiki J, Kuroda M (April 2012). "Identification of a novel role of Septin 10 in paclitaxel-resistance in cancers through a functional genomics screen". Cancer Science. 103 (4): 821–7. doi:10.1111/j.1349-7006.2012.02221.x. PMC 7659246. PMID 22320903. S2CID 3456503.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.