Protein transport protein Sec24C is a protein that in humans is encoded by the SEC24C gene.[5][6][7]

SEC24C
Available structures
PDBHuman UniProt search: PDBe RCSB
Identifiers
AliasesSEC24C, SEC24 homolog C, COPII coat complex component
External IDsOMIM: 607185; MGI: 1919746; HomoloGene: 3615; GeneCards: SEC24C; OMA:SEC24C - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_004922
NM_198597

NM_001168273
NM_172596

RefSeq (protein)

NP_004913
NP_940999

n/a

Location (UCSC)Chr 10: 73.74 – 73.77 MbChr 14: 20.72 – 20.74 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

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The protein encoded by this gene is a member of the SEC24 subfamily of the SEC23/SEC24 family, which is involved in vesicle trafficking. The encoded protein has similarity to yeast Sec24p component of COPII. COPII is the coat protein complex responsible for vesicle budding from the ER. The product of this gene may play a role in shaping the vesicle, as well as in cargo selection and concentration. Alternatively spliced transcript variants encoding the same protein have been identified.[7]

Interactions

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SEC24C has been shown to interact with SEC23A.[8]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000176986Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000039367Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Tani K, Oyama Y, Hatsuzawa K, Tagaya M (May 1999). "Hypothetical protein KIAA0079 is a mammalian homologue of yeast Sec24p". FEBS Lett. 447 (2–3): 247–50. doi:10.1016/S0014-5793(99)00303-8. PMID 10214955. S2CID 41796761.
  6. ^ Nomura N, Nagase T, Miyajima N, Sazuka T, Tanaka A, Sato S, Seki N, Kawarabayasi Y, Ishikawa K, Tabata S (1994). "Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1". DNA Res. 1 (5): 223–9. doi:10.1093/dnares/1.5.223. PMID 7584044.
  7. ^ a b "Entrez Gene: SEC24C SEC24 related gene family, member C (S. cerevisiae)".
  8. ^ Pagano A, Letourneur F, Garcia-Estefania D, Carpentier JL, Orci L, Paccaud JP (Mar 1999). "Sec24 proteins and sorting at the endoplasmic reticulum". J. Biol. Chem. 274 (12): 7833–40. doi:10.1074/jbc.274.12.7833. PMID 10075675.

Further reading

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