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U4/U6.U5 tri-snRNP-associated protein 1 is a protein that in humans is encoded by the SART1 gene.[5][6] This gene encodes two proteins, the SART1(800) protein expressed in the nucleus of the majority of proliferating cells, and the SART1(259) protein expressed in the cytosol of epithelial cancers. The SART1(259) protein is translated by the mechanism of -1 frameshifting during posttranscriptional regulation. The two encoded proteins are thought to be involved in the regulation of proliferation. Both proteins have tumor-rejection antigens. The SART1(259) protein possesses tumor epitopes capable of inducing HLA-A2402-restricted cytotoxic T lymphocytes in cancer patients. This SART1(259) antigen may be useful in specific immunotherapy for cancer patients and may serve as a paradigmatic tool for the diagnosis and treatment of patients with atopy. The SART1(259) protein is found to be essential for the recruitment of the tri-snRNP to the pre-spliceosome in the spliceosome assembly pathway.[6]

SART1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesSART1, Ara1, HOMS1, SART1259, SNRNP110, Snu66, squamous cell carcinoma antigen recognized by T-cells 1, HAF, U4/U6.U5 tri-snRNP-associated protein 1, spliceosome associated factor 1, recruiter of U4/U6.U5 tri-snRNP
External IDsOMIM: 605941 MGI: 1309453 HomoloGene: 133770 GeneCards: SART1
Gene location (Human)
Chromosome 11 (human)
Chr.Chromosome 11 (human)[1]
Chromosome 11 (human)
Genomic location for SART1
Genomic location for SART1
Band11q13.1Start65,961,728 bp[1]
End65,980,137 bp[1]
RNA expression pattern
PBB GE SART1 200052 s at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_005146

NM_016882

RefSeq (protein)

NP_005137

NP_058578

Location (UCSC)Chr 11: 65.96 – 65.98 MbChr 19: 5.38 – 5.39 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

ReferencesEdit

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000175467 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000039148 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:".
  4. ^ "Mouse PubMed Reference:".
  5. ^ Shichijo S, Nakao M, Imai Y, Takasu H, Kawamoto M, Niiya F, Yang D, Toh Y, Yamana H, Itoh K (Mar 1998). "A gene encoding antigenic peptides of human squamous cell carcinoma recognized by cytotoxic T lymphocytes". J Exp Med. 187 (3): 277–88. doi:10.1084/jem.187.3.277. PMC 2212124. PMID 9449708.
  6. ^ a b "Entrez Gene: SART1 squamous cell carcinoma antigen recognized by T cells".

Further readingEdit