S100 calcium-binding protein A5 (S100A5) is a protein that is encoded by the S100A5 gene in humans.[5][6]

S100A5
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesS100A5, S100D, S100 calcium binding protein A5
External IDsOMIM: 176991; MGI: 1338915; HomoloGene: 2224; GeneCards: S100A5; OMA:S100A5 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_002962
NM_001394232
NM_001394233
NM_001394234

NM_011312

RefSeq (protein)

NP_002953

NP_035442

Location (UCSC)Chr 1: 153.54 – 153.54 MbChr 3: 90.52 – 90.52 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells and are involved in the regulation of a number of cellular processes, such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein has a Ca2+ affinity 20- to 100-fold higher than the other S100 proteins studied under identical conditions. This protein also binds Zn2+ and Cu2+, and Cu2+ strongly which impairs the binding of Ca2+. This protein is expressed in very restricted regions of the adult brain.[6]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000196420Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000001023Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Engelkamp D, Schafer BW, Mattei MG, Erne P, Heizmann CW (Aug 1993). "Six S100 genes are clustered on human chromosome 1q21: identification of two genes coding for the two previously unreported calcium-binding proteins S100D and S100E". Proc Natl Acad Sci U S A. 90 (14): 6547–51. Bibcode:1993PNAS...90.6547E. doi:10.1073/pnas.90.14.6547. PMC 46969. PMID 8341667.
  6. ^ a b "Entrez Gene: S100A5 S100 calcium binding protein A5".

Further reading

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