Rhodosporidiobolus fluvialis is a species of fungus in the family Sporidiobolaceae. It is a human fungal pathogen that exhibits resistance to antifungal compounds like fluconazole and caspofungin.[2]
| Rhodosporidiobolus fluvialis | |
|---|---|
Scientific classification 
| |
| Domain: | Eukaryota |
| Kingdom: | Fungi |
| Division: | Basidiomycota |
| Class: | Microbotryomycetes |
| Order: | Sporidiobolales |
| Family: | Sporidiobolaceae |
| Genus: | Rhodosporidiobolus |
| Species: | R. fluvialis
|
| Binomial name | |
| Rhodosporidiobolus fluvialis (Fell, Kurtzman, Tallman & J.D.Buck) Q.M.Wang, F.Y.Bai, M.Groenew. & Boekhout[1]
| |
| Synonyms[1] | |
|
Rhodosporidium fluviale Fell, Kurtzman, Tallman & J.D. Buck 1988 | |
Antifungal resistance
editRhodosporidiobolus fluvialis was isolated from two independent patients. It can proliferate well at 37 °C (99 °F), a temperature similar to the human body's internal temperature. When it is incubated at 37 °C (99 °F), reactive oxygen species accumulate and damage its DNA, which causes mutations that lead to the development of resistance to amphotericin-B.[3]
R. fluvialis colonies can be pigmented due to the accumulation of carotenoids in the cells. Carotenoid production has been associated with its resistance to caspofungin.[3]
References
edit- ^ a b "Rhodosporidiobolus fluvialis (Fell, Kurtzman, Tallman & J.D.Buck) Q.M.Wang, F.Y.Bai, M.Groenew. & Boekhout". Global Biodiversity Information Facility. Retrieved 17 July 2024.
- ^ Bowman, Verity. "Are warmer temperatures causing fungi to attack humans? Two deaths in China suggest it may be". The Telegraph.
- ^ a b Huang, Jingjing; Hu, Pengjie; Ye, Leixin; Shen, Zhenghao; Chen, Xinfei; Liu, Fang; Xie, Yuyan; Yu, Jinhan; Fan, Xin; Xiao, Meng; Tsui, Clement K. M.; Wang, Weiping; Li, Yingxing; Zhang, Ge; Wong, Koon Ho (July 2024). "Pan-drug resistance and hypervirulence in a human fungal pathogen are enabled by mutagenesis induced by mammalian body temperature". Nature Microbiology. 9 (7): 1686–1699. doi:10.1038/s41564-024-01720-y. ISSN 2058-5276. PMID 38898217.
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